Browse by UCL people
Group by: Type | Date
Number of items: 50.
2025
Moreno, Rui;
Rhodes, Andrew;
Ranzani, Otavio;
Salluh, Jorge IF;
Berger-Estilita, Joana;
Coopersmith, Craig M;
Juffermans, Nicole P;
... Singer, Mervyn; + view all
(2025)
Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score.
Jama Network Open
, 8
(10)
, Article e2545040. 10.1001/jamanetworkopen.2025.45040.
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Ranzani, Otavio T;
Singer, Mervyn;
Salluh, Jorge IF;
Shankar-Hari, Manu;
Pilcher, David;
Berger-Estilita, Joana;
Coopersmith, Craig M;
... Moreno, Rui; + view all
(2025)
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score.
Journal of the American Medical Association
10.1001/jama.2025.20516.
(In press).
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Villa, A;
Xue, H;
Scully, M;
David, S;
Bercades, G;
Brealey, D;
Singer, M;
... Arulkumaran, N; + view all
(2025)
Plasma from patients with sepsis induces release of neutrophil extracellular traps from healthy volunteer neutrophils ex vivo.
British Journal of Anaesthesia
, 135
(4)
pp. 1116-1118.
10.1016/j.bja.2025.06.046.
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2024
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Pisciotta, Walter;
Passannante, Alberto;
Arina, Pietro;
Alotaibi, Khalid;
Ambler, Gareth;
Arulkumaran, Nishkantha;
(2024)
High-flow nasal oxygen versus conventional oxygen therapy and noninvasive ventilation in COVID-19 respiratory failure: a systematic review and network meta-analysis of randomised controlled trials.
British Journal of Anaesthesia
10.1016/j.bja.2023.12.022.
(In press).
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Snow, Timothy Arthur Chandos;
Serisier, Aimee;
Brealey, David;
Singer, Mervyn;
Arulkumaran, Nishkantha;
(2024)
Immunophenotyping patients with sepsis and underlying haematological malignancy reveals defects in monocyte and lymphocyte function.
Intensive Care Medicine Experimental
, 12
(1)
, Article 3. 10.1186/s40635-023-00578-4.
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2023
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Arulkumaran, Nishkantha;
Singer, Mervyn;
Howorka, Stefan;
Burns, Jonathan R;
(2023)
Creating complex protocells and prototissues using simple DNA building blocks.
Nature Communications
, 14
, Article 1314. 10.1038/s41467-023-36875-5.
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Choi, Sang Ho;
Cesar, Antoni;
Snow, Timothy Arthur Chandos;
Saleem, Naveed;
Arulkumaran, Nishkantha;
Singer, Mervyn;
(2023)
Efficacy of Doxycycline for Mild-to-moderate Community-acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Clinical Infectious Diseases
, 76
(4)
pp. 683-691.
10.1093/cid/ciac615.
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Choi, Sang-Ho;
Cesar, Antoni;
Snow, Timothy Arthur Chandos;
Saleem, Naveed;
Arulkumaran, Nishkantha;
Singer, Mervyn;
(2023)
Respiratory fluoroquinolone monotherapy versus β-lactam plus macrolide combination therapy for hospitalized adults with community-acquired pneumonia: A systematic review and meta-analysis of randomised controlled trials.
International Journal of Antimicrobial Agents
, 62
(3)
, Article 106905. 10.1016/j.ijantimicag.2023.106905.
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Saleem, Naveed;
Kulkarni, Adarsh;
Chandos Snow, Timothy Arthur;
Ambler, Gareth;
Singer, Mervyn;
Arulkumaran, Nishkantha;
(2023)
Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.
Chest
, 163
(3)
pp. 484-497.
10.1016/j.chest.2022.08.2229.
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Stein, DF;
Foley, C;
Byott, M;
Nastouli, E;
Ambler, G;
Arulkumaran, N;
(2023)
Biological sex is associated with heterogeneous responses to IL-6 receptor inhibitor treatment in COVID-19—A retrospective cohort study.
Scientific Reports
, 13
(1)
, Article 13504. 10.1038/s41598-023-40744-y.
(In press).
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2022
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Ahmed, WUR;
Bhatia, S;
McLean, KA;
Khaw, R;
Baker, D;
Kamarajah, SK;
Bell, S;
... Eftychiou, S; + view all
(2022)
Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
BJS Open
, 6
(1)
, Article zrab150. 10.1093/bjsopen/zrab150.
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Chan, XHS;
O'Connor, CJ;
Martyn, E;
Clegg, AJ;
Choy, BJK;
Soares, AL;
Shulman, R;
... Wilson, APR; + view all
(2022)
Reducing broad-spectrum antibiotic use in intensive care unit between first and second waves of COVID-19 did not adversely affect mortality.
Journal of Hospital Infection
, 124
pp. 37-46.
10.1016/j.jhin.2022.03.007.
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Peters, VBM;
Arulkumaran, N;
Melis, MJ;
Gaupp, C;
Roger, T;
Shankar-Hari, M;
Singer, M;
(2022)
Butyrate Supplementation Exacerbates Myocardial and Immune Cell Mitochondrial Dysfunction in a Rat Model of Faecal Peritonitis.
Life
, 12
(12)
, Article 2034. 10.3390/life12122034.
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Saleem, Naveed;
Ryckaert, Francis;
Snow, Timothy Arthur Chandos;
Satta, Giovanni;
Singer, Mervyn;
Arulkumaran, Nishkantha;
(2022)
Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments.
Clinical Microbiology and Infection
, 28
(7)
pp. 936-945.
10.1016/j.cmi.2021.12.021.
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Snow, Timothy Arthur Chandos;
Cesar, Antonio;
Singer, Mervyn;
Arulkumaran, Nishkantha;
(2022)
Clarithromycin as an immunomodulator in sepsis: still a (IN)CLASS act.
Critical Care
, 26
, Article 238. 10.1186/s13054-022-04104-y.
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Snow, Timothy Arthur Chandos;
Longobardo, Alessia;
Brealey, David;
Down, Jim;
Satta, Giovanni;
Singer, Mervyn;
Arulkumaran, Nishkantha;
(2022)
Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19.
Journal of Infection and Chemotherapy
, 28
(7)
pp. 948-954.
10.1016/j.jiac.2022.04.001.
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Zacharias, Harry;
Mungara, Ritwik;
Wilson, Andrew Peter;
Singer, Mervyn;
Arulkumaran, Nishkantha;
(2022)
The utility of CRP with the use of dexamethasone and Tocilizumab in critically ill patients with COVID-19.
Journal of Critical Care
, 70
, Article 154053. 10.1016/j.jcrc.2022.154053.
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2021
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Arina, P;
Baso, B;
Moro, V;
Patel, H;
Ambler, G;
Voegele, P;
Arulkumaran, N;
... Singer, M; + view all
(2021)
Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure.
Intensive Care Medicine
, 47
pp. 237-239.
10.1007/s00134-020-06304-y.
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Arulkumaran, N;
Lanphere, C;
Gaupp, C;
Burns, JR;
Singer, M;
Howorka, S;
(2021)
DNA Nanodevices with Selective Immune Cell Interaction and Function.
ACS Nano
, 15
(3)
pp. 4394-4404.
10.1021/acsnano.0c07915.
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Arulkumaran, N;
Pollen, SJ;
Tidswell, R;
Gaupp, C;
Peters, VBM;
Stanzani, G;
Snow, TAC;
... Singer, M; + view all
(2021)
Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis in rats.
British Journal of Anaesthesia
, 127
(4)
pp. 577-586.
10.1016/j.bja.2021.05.036.
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Arulkumaran, N;
Snow, TAC;
Kulkarni, A;
Brealey, D;
Rickman, H;
Rees-Spear, C;
Spyer, MJ;
... Singer, M; + view all
(2021)
Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort.
Critical Care Explorations
, 3
(8)
, Article e0488. 10.1097/cce.0000000000000488.
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Arulkumaran, N;
Snow, TAC;
Kulkarni, A;
Brealey, D;
Rickman, HM;
Rees-Spear, C;
Spyer, MJ;
... Singer, M; + view all
(2021)
Influence of IL-6 levels on patient survival in COVID-19.
Journal of Critical Care
, 66
pp. 123-125.
10.1016/j.jcrc.2021.08.013.
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Arulkumaran, N;
Green, J;
Khan, A;
Bonnici, T;
Longobardo, A;
Singer, M;
(2021)
Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS- A single centre retrospective analysis.
Journal of Critical Care
, 62
pp. 289-291.
10.1016/j.jcrc.2021.01.001.
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Arulkumaran, N;
Snow, TAC;
Kulkarni, A;
Brealey, D;
Rickman, HM;
Rees-Spear, C;
Spyer, MJ;
... Singer, M; + view all
(2021)
Sex differences in immunological responses to COVID-19: a cross-sectional analysis of a single-centre cohort.
British Journal of Anaesthesia
10.1016/j.bja.2021.05.013.
(In press).
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Arulkumaran, N;
Thomas, M;
Brealey, D;
Alwan, F;
Singh, D;
Lunn, M;
Welch, A;
... Scully, M; + view all
(2021)
Plasma exchange for COVID-19 thrombo-inflammatory disease.
EJHaem
, 2
(1)
pp. 26-32.
10.1002/jha2.140.
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Frampton, D;
Rampling, T;
Cross, A;
Bailey, H;
Heaney, J;
Byott, M;
Scott, R;
... Nastouli, E; + view all
(2021)
Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study.
Lancet Infectious Diseases
10.1016/S1473-3099(21)00170-5.
(In press).
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Longobardo, A;
Montanari, C;
Shulman, R;
Benhalim, S;
Singer, M;
Arulkumaran, N;
(2021)
Inhaled nitric oxide minimally improves oxygenation in COVID-19 related acute respiratory distress syndrome.
British Journal of Anaesthesia
, 126
(1)
e44-e46.
10.1016/j.bja.2020.10.011.
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Longobardo, A;
Snow, TAC;
Montanari, C;
Shulman, R;
Singer, M;
Arulkumaran, N;
(2021)
COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study.
Journal of Critical Care
, 62
pp. 46-48.
10.1016/j.jcrc.2020.11.012.
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McMillan, Tim;
Jones, Conor;
O'Connor, Cavan J;
Nolan, Daniel;
Chan, Xin Hui S;
Ellis, Jayne;
Thakker, Clare;
... Arulkumaran, Nishkantha; + view all
(2021)
Risk factors associated with bloodstream infections among critically ill patients with COVID-19.
Journal of Infection
, 83
(5)
E1-E3.
10.1016/j.jinf.2021.09.010.
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Samra, K;
Kuganesan, M;
Smith, W;
Kleyman, A;
Tidswell, R;
Arulkumaran, N;
Singer, M;
(2021)
The Pharmacology and Therapeutic Utility of Sodium Hydroselenide.
International Journal of Molecular Sciences
, 22
(6)
, Article 3258. 10.3390/ijms22063258.
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Snow, TAC;
Saleem, N;
Ambler, G;
Nastouli, E;
McCoy, LE;
Singer, M;
Arulkumaran, N;
(2021)
Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regression.
British Journal of Anaesthesia
, 127
(6)
pp. 834-844.
10.1016/j.bja.2021.07.033.
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Snow, TAC;
Saleem, N;
Ambler, G;
Nastouli, E;
Singer, M;
Arulkumaran, N;
(2021)
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials.
Intensive Care Medicine
, 47
(6)
pp. 641-652.
10.1007/s00134-021-06416-z.
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2020
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Arulkumaran, N;
Brealey, D;
Howell, D;
Singer, M;
(2020)
Use of non-invasive ventilation for patients with COVID-19: a cause for concern?
The Lancet Respiratory Medicine
, 8
(6)
, Article e45. 10.1016/S2213-2600(20)30181-8.
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Snow, TAC;
Singer, M;
Arulkumaran, N;
(2020)
Immunomodulators in COVID-19: Two Sides to Every Coin.
American Journal of Respiratory and Critical Care Medicine
, 202
(10)
pp. 1460-1461.
10.1164/rccm.202008-3148le.
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2019
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Arulkumaran, N;
Navaratnarajah, A;
Pillay, C;
Brown, W;
Duncan, N;
McLean, A;
Taube, D;
(2019)
Causes and risk factors for acute dialysis initiation among patients with end-stage kidney disease-a large retrospective observational cohort study.
Clinical Kidney Journal
, 12
(4)
pp. 550-558.
10.1093/ckj/sfy118.
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Metaxa, V;
Anagnostou, D;
Vlachos, S;
Arulkumaran, N;
van Dusseldorp, I;
Bensemmane, S;
Aslakson, R;
... Curtis, R; + view all
(2019)
Palliative care interventions in intensive care unit patients - a systematic review protocol.
Systematic Reviews
, 8
, Article 148. 10.1186/s13643-019-1064-y.
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2018
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Arulkumaran, N;
McLaren, CS;
Arulkumaran, K;
Philips, BJ;
Cecconi, M;
(2018)
An analysis of emergency tracheal intubations in critically ill patients by critical care trainees.
Journal of the Intensive Care Society
, 19
(3)
pp. 180-187.
10.1177/1751143717749686.
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Arulkumaran, N;
Pollen, S;
Greco, E;
Courtneidge, H;
Hall, AM;
Duchen, MR;
Tam, FWK;
... Singer, M; + view all
(2018)
Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury.
Critical Care Medicine
, 46
(4)
e318-e325.
10.1097/CCM.0000000000002937.
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Arulkumaran, N;
Sixma, ML;
Pollen, S;
Ceravola, E;
Jentho, E;
Prendecki, M;
Bass, PS;
... Singer, M; + view all
(2018)
P2X7receptor antagonism ameliorates renal dysfunction in a rat model of sepsis.
Physiological Reports
, 6
(5)
, Article e13622. 10.14814/phy2.13622.
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Drake, TM;
Cheung, LK;
Gaba, F;
Glasbey, J;
Griffiths, N;
Helliwell, RJ;
Huq, T;
... Naruka, V; + view all
(2018)
Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study.
Anaesthesia
, 73
(10)
pp. 1214-1222.
10.1111/anae.14349.
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Galloway, M;
Hegarty, A;
McGill, S;
Arulkumaran, N;
Brett, SJ;
Harrison, D;
(2018)
The Effect of ICU Out-of-Hours Admission on Mortality: A Systematic Review and Meta-Analysis.
[Review].
Critical Care Medicine
, 46
(2)
pp. 290-299.
10.1097/CCM.0000000000002837.
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Kang, A;
Antonelou, M;
Wong, NL;
Tanna, A;
Arulkumaran, N;
Tam, FWK;
Pusey, CD;
(2018)
High Incidence of Arterial and Venous Thrombosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
The Journal of Rheumatology
, 2018
, Article 170896. 10.3899/jrheum.170896.
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2017
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Arulkumaran, N;
Harrison, DA;
Brett, SJ;
(2017)
Association between day and time of admission to critical care and acute hospital outcome for unplanned admissions to adult general critical care units: cohort study exploring the 'weekend effect'.
British Journal of Anaesthesia
, 118
(1)
pp. 112-122.
10.1093/bja/aew398.
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Arulkumaran, N;
Sixma, ML;
Jentho, E;
Ceravola, E;
Bass, PS;
Kellum, JA;
Unwin, RJ;
... Singer, M; + view all
(2017)
Sequential analysis of a panel of biomarkers and pathologic findings in a resuscitated rat model of sepsis and recovery.
Critical Care Medicine
, 45
(8)
e821-e830.
10.1097/CCM.0000000000002381.
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McAdoo, SP;
Tanna, A;
Hruskova, Z;
Holm, L;
Weiner, M;
Arulkumaran, N;
Kang, A;
... Pusey, CD; + view all
(2017)
Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients.
Kidney International
, 92
(3)
pp. 693-702.
10.1016/j.kint.2017.03.014.
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Toscani, L;
Aya, HD;
Antonakaki, D;
Bastoni, D;
Watson, X;
Arulkumaran, N;
Rhodes, A;
(2017)
What is the impact of the fluid challenge technique on diagnosis of fluid responsiveness? A systematic review and meta-analysis.
Critical Care
, 21
, Article 207. 10.1186/s13054-017-1796-9.
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2016
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Arulkumaran, N;
(2016)
P2X7 receptor and Sepsis-Induced Acute Kidney Injury.
Doctoral thesis , UCL (University College London).
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Pattison, N;
Arulkumaran, N;
Humphreys, S;
Walsh, T;
(2016)
Exploring obstacles to critical care trials in the UK: A qualitative investigation.
Journal of the Intensive Care Society
, 18
(1)
pp. 36-46.
10.1177/1751143716663749.
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2013
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Arulkumaran, N;
Turner, CM;
Sixma, ML;
Singer, M;
Unwin, R;
Tam, FW;
(2013)
Purinergic signaling in inflammatory renal disease.
Front Physiol
, 4
, Article 194. 10.3389/fphys.2013.00194.
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2011
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Arulkumaran, N;
Jawad, S;
Smith, SW;
Harper, L;
Brogan, P;
Pusey, CD;
Salama, AD;
(2011)
Long- term outcome of paediatric patients with ANCA vasculitis.
Pediatric Rheumatology
, 9
, Article 12. 10.1186/1546-0096-9-12.
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