Browse by UCL people
Group by: Type | Date
Number of items: 39.
Article
Albay, A;
Artim-Esen, B;
Pericleous, C;
Wincup, C;
Giles, I;
Rahman, A;
McDonnell, T;
(2019)
Domain I of β2GPI is capable of blocking serum IgA antiphospholipid antibodies binding in vitro: an effect enhanced by PEGylation.
Lupus
10.1177/0961203319851571.
(In press).
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Artim-Esen, B;
Smoktunowicz, N;
McDonnell, T;
Ripoll, VM;
Pericleous, C;
Mackie, I;
Robinson, E;
... Giles, I; + view all
(2017)
Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.
Scientific Reports
, 7
(1)
, Article 10788. 10.1038/s41598-017-11315-9.
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Bourke, LT;
McDonnell, T;
McCormick, J;
Pericleous, C;
Ripoll, VM;
Giles, I;
Rahman, A;
... Ioannou, Y; + view all
(2017)
Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK.
Cell Death & Disease
, 8
(1)
, Article e2549. 10.1038/cddis.2016.235.
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Bradford, HF;
Lalaurie, CJ;
Gor, J;
Gao, X;
Pericleous, C;
Perkins, SJ;
Britt, H;
... McDonnell, TCR; + view all
(2025)
Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies.
Journal of Thrombosis and Haemostasis
, 23
(6)
pp. 1864-1878.
10.1016/j.jtha.2025.02.015.
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Bradford, HF;
McDonnell, TCR;
Stewart, A;
Skelton, A;
Ng, J;
Baig, Z;
Fraternali, F;
... Mauri, C; + view all
(2024)
Thioredoxin is a metabolic rheostat controlling regulatory B cells.
Nature Immunology
10.1038/s41590-024-01798-w.
(In press).
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Buchholz, I;
McDonnell, T;
Nestler, P;
Tharad, S;
Kulke, M;
Radziszewska, A;
Ripoll, VM;
... Delcea, M; + view all
(2021)
Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding.
Scientific Reports
, 11
, Article 4542. 10.1038/s41598-021-84021-2.
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Ciurtin, Coziana;
Helmy, Ghada Adly;
Ferreira, Alexia Correia;
Manson, Jessica J;
Jury, Elizabeth C;
McDonnell, Thomas;
(2024)
A tale of two functions: C-reactive protein complement-ary structures and their role in rheumatoid arthritis.
Clinical Immunology
, 265
, Article 110281. 10.1016/j.clim.2024.110281.
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Coelewij, L;
Waddington, KE;
Robinson, GA;
Chocano, E;
McDonnell, T;
Farinha, F;
Peng, J;
... Pineda-Torra, I; + view all
(2021)
Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus.
Arteriosclerosis, Thrombosis, and Vascular Biology
10.1161/ATVBAHA.120.315321.
(In press).
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Cornish, E;
Filipovic, I;
Åsenius, F;
Williams, D;
McDonnell, T;
(2020)
Innate immune responses to acute viral infection during pregnancy.
Frontiers in Immunology
10.3389/fimmu.2020.572567.
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Efthymiou, M;
Arachchillage, DRJ;
Lane, PJ;
O'Keeffe, AG;
McDonnell, T;
Cohen, H;
Mackie, IJ;
(2018)
Antibodies against TFPI and protein C are associated with a severe thrombotic phenotype in patients with and without antiphospholipid syndrome.
Thrombosis Research
, 170
pp. 60-68.
10.1016/j.thromres.2018.08.003.
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Farinha, F;
Pepper, RJ;
Oliveira, DG;
McDonnell, T;
Isenberg, DA;
Rahman, A;
(2020)
Outcomes of membranous and proliferative lupus nephritis – analysis of a single-centre cohort with more than 30 years of follow-up.
Rheumatology
10.1093/rheumatology/keaa103.
(In press).
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Jury, E;
Manson, J;
Ciurtin, C;
Bradford, C;
McDonnell, T;
Isenberg, D;
Robinson, G;
(2019)
Characterization of a subset of patients with rheumatoid arthritis for whom current management strategies are inadequate.
ACR Open Rheumatology
, 1
(3)
pp. 145-155.
10.1002/acr2.1021.
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Lalaurie, CJ;
Kulke, M;
Geist, N;
Delcea, M;
Dalby, PA;
McDonnell, TCR;
(2025)
The J-shape of β2GPI reveals a cryptic discontinuous epitope across domains I and II.
Journal of Structural Biology X
, 12
, Article 100135. 10.1016/j.yjsbx.2025.100135.
(In press).
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Lanna, A;
Gomes, DC;
Muller-Durovic, B;
McDonnell, T;
Escors, D;
Gilroy, DW;
Lee, JH;
... Akbar, AN; + view all
(2017)
A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.
Nature Immunology
, 18
(3)
pp. 354-363.
10.1038/ni.3665.
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McDonnell, Thomas;
Amarnani, Raj;
Spicer, Carina;
Jbari, Hajar;
Pericleous, Charis;
Spiteri, Valentina A;
Wincup, Chris;
... Giles, Ian; + view all
(2022)
Antibodies to FXa and thrombin in patients with SLE differentially regulate C3 and C5 cleavage.
Lupus Science & Medicine
, 9
(1)
, Article e000738. 10.1136/lupus-2022-000738.
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McDonnell, T;
Artim-Esen, B;
Wincup, C;
Ripoll, VM;
Isenberg, D;
Giles, IP;
Rahman, A;
(2018)
Antiphospholipid Antibodies to Domain I of Beta-2-Glycoprotein I Show Different Subclass Predominance in Comparison to Antibodies to Whole Beta-2-glycoprotein I.
Frontiers in Immunology
, 9
(2224)
10.3389/fimmu.2018.02244.
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McDonnell, T;
Ioannou, Y;
Rahman, A;
(2014)
PEGylated drugs in rheumatology--why develop them and do they work?
Rheumatology
, 53
(3)
pp. 391-396.
10.1093/rheumatology/ket278.
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McDonnell, T;
Pericleous, C;
Laurine, E;
Tommasi, R;
Garza-Garcia, A;
Giles, I;
Ioannou, Y;
(2015)
Development of a high yield expression and purification system for Domain I of Beta-2-glycoprotein I for the treatment of APS.
BMC Biotechnology
, 15
, Article 104. 10.1186/s12896-015-0222-0.
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McDonnell, T;
Wincup, C;
Buchholz, I;
Pericleous, C;
Giles, I;
Ripoll, V;
Cohen, H;
... Rahman, A; + view all
(2019)
The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS.
Blood Reviews
, Article 100610. 10.1016/j.blre.2019.100610.
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McDonnell, TCR;
Willis, R;
Pericleous, C;
Ripoll, VM;
Giles, IP;
Isenberg, DA;
Brasier, AR;
... Rahman, A; + view all
(2018)
PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome.
Frontiers in Immunology
, 9
, Article 2413. 10.3389/fimmu.2018.02413.
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McDonnell, TCR;
Wincup, C;
Rahman, A;
Giles, I;
(2018)
Going viral in rheumatology: Using social media to show that mechanistic research is relevant to patients with lupus and antiphospholipid syndrome.
Rheumatology Advances in Practice
, 2
(1)
, Article rky003. 10.1093/rap/rky003.
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Muñoz Muñoz, Candido;
Farinha, Filipa;
McDonnell, Thomas;
J'bari, Hajar;
Nguyen, Hanh;
Isenberg, David;
Rahman, Anisur;
... Giles, Ian; + view all
(2024)
Comparing pregnancy outcomes in patients with Systemic Lupus Erythematosus (SLE) and Undifferentiated Connective Tissue Disease (UCTD): a descriptive cohort study.
Revista Clínica Española: Journal of Internal Medicine
, 224
(6)
pp. 357-365.
10.1016/j.rceng.2024.04.013.
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Nagel, F;
Palm, GJ;
Geist, N;
McDonnell, TCR;
Susemihl, A;
Girbardt, B;
Mayerle, J;
... Delcea, M; + view all
(2022)
Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin.
International Journal of Molecular Sciences
, 23
(7)
p. 3468.
10.3390/ijms23073468.
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Pericleous, C;
D'Souza, A;
McDonnell, T;
Ripoll, VM;
Leach, O;
Isenberg, D;
Giles, I;
(2019)
Antiphospholipid antibody levels in early systemic lupus erythematosus: are they associated with subsequent mortality and vascular events?
Rheumatology
, Article kez239. 10.1093/rheumatology/kez239.
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Pericleous, C;
Ferreira, I;
Borghi, O;
Pregnolato, F;
McDonnell, T;
Garza-Garcia, A;
Driscoll, P;
... Rahman, A; + view all
(2016)
Measuring IgA anti-β2-glycoprotein I and IgG/IgA anti-domain I antibodies adds value to current serological assays for the antiphospholipid syndrome.
PLoS One
, 11
(6)
, Article e0156407. 10.1371/journal.pone.0156407.
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Ripoll, VM;
Pregnolato, F;
Mazza, S;
Bodio, C;
Grossi, C;
McDonnell, T;
Pericleous, C;
... Giles, IP; + view all
(2018)
Gene expression profiling identifies distinct molecular signatures in thrombotic and obstetric antiphospholipid syndrome.
Journal of Autoimmunity
10.1016/j.jaut.2018.07.002.
(In press).
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Robinson, GA;
Mcdonnell, T;
Wincup, C;
Martin-Gutierrez, L;
Wilton, J;
Kalea, AZ;
Ciurtin, C;
... Jury, EC; + view all
(2019)
Diet and lupus: what do the patients think?
Lupus
, 28
(6)
pp. 755-763.
10.1177/0961203319845473.
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Rodgers, Nicole;
Lalaurie, Christophe;
McDonnell, Thomas;
(2025)
Simulation of the trimeric globular head of C1q reveals temperature-sensitive network: implications for inflammation.
Journal of Molecular Modeling
, 31
, Article 247. 10.1007/s00894-025-06464-y.
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Segura, BT;
Bernstein, BS;
McDonnell, T;
Wincup, C;
M Ripoll, V;
Giles, I;
Isenberg, D;
(2019)
Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort.
[Corrigendum].
Rheumatology
, Article kez516. 10.1093/rheumatology/kez516.
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Segura, BT;
Bernstein, BS;
McDonnell, T;
Wincup, C;
Ripoll, V;
Giles, I;
Isenberg, D;
(2020)
Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort.
Rheumatology
, 59
(3)
pp. 524-533.
10.1093/rheumatology/kez292.
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Shaw, B;
McDonnell, T;
Radley, E;
Thomas, B;
Smith, L;
Davenport, CAL;
Gonzalez, S;
... Layfield, R; + view all
(2023)
Preservation of whole antibodies within ancient teeth.
iScience
, 26
(9)
, Article 107575. 10.1016/j.isci.2023.107575.
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Uludağ, Ö;
Çinar, S;
McDonnell, T;
Çene, E;
Yalçinkaya, Y;
Gül, A;
İnanç, M;
(2023)
Thrombotic risk assessment in antiphospholipid syndrome: do noncriteria antibodies contribute?
Turkish Journal of Medical Sciences
, 53
(5)
pp. 1067-1074.
10.55730/1300-0144.5671.
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Wilkinson, Meredyth G Ll;
Moulding, Dale;
McDonnell, Thomas CR;
Orford, Michael;
Wincup, Chris;
Ting, Joanna YJ;
Otto, Georg W;
... Wedderburn, Lucy R; + view all
(2022)
Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis.
Annals of the Rheumatic Diseases
10.1136/ard-2022-223469.
(In press).
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Wincup, C;
McDonnell, TCR;
Rahman, A;
(2019)
Menorrhagia: an underappreciated problem in pre-menopausal women with systemic lupus erythematosus.
Lupus
10.1177/0961203319851868.
(In press).
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Conference item
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Martin-Gutierrez, L;
Wilton, J;
Robinson, G;
McDonnell, T;
Isenberg, D;
Wincup, C;
Kalea, A;
... Ciurtin, C; + view all
(2019)
Designing a diet interventional study for autoimmune rheumatic disease: asking patients what they think.
Presented at: EULAR: Annual European Congress of Rheumatology, Madrid, Spain.
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McDonnell, T;
Bradford, C;
Raj, D;
Ciurtin, C;
Jury, E;
Manson, J;
(2018)
Differential activation of complement in rheumatoid arthritis.
Presented at: Annual European Congress of Rheumatology - European League Against Rheumatism (EULAR) - 2018, Amsterdam, Netherlands.
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Robinson, G;
McDonnell, T;
Wincup, C;
Martin-Gutierrez, L;
Wilton, J;
Kalea, A;
Ciurtin, C;
... Jury, E; + view all
(2019)
Cardiovascular disease in SLE: what do patients think about using diet as a therapeutic?
Presented at: European League Against Rheumatism (EULAR) 2019, Madrid, Spain.
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Poster
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Bradford, Hannah F;
Lalaurie, Christophe J;
God, Jayesh;
Gao, Xin;
Pericleous, Charis;
Perkins, Stephen J;
Britt, Hannah;
... McDonnell, Thomas CR; + view all
(2024)
Plasmin-Clipped Beta-2-Glycoprotein I: Novel Structures Lead to Increased Antibody Binding.
Presented at: 7th European Conference of Immunology, Dublin, Ireland.
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Thesis
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McDonnell, TCR;
(2016)
Does PEGylated DI have the potential to be an effective therapeutic for Antiphospholipid Syndrome?
Doctoral thesis , UCL (University College London).
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