Browse by UCL people
Group by: Type | Date
Number of items: 31.
Article
Arber, C;
Villegas-Llerena, C;
Toombs, J;
Pocock, JM;
Ryan, NS;
Fox, NC;
Zetterberg, H;
... Wray, S; + view all
(2019)
Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout.
Brain Communications
10.1093/braincomms/fcz024.
(In press).
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Boudesco, Christophe;
Nonneman, Annelies;
Cinti, Alessandro;
Picardi, Paola;
Redaelli, Loredana;
Swijsen, Sofie;
Roewe, Julian;
... Pradier, Laurent; + view all
(2022)
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells.
Glia
10.1002/glia.24252.
(In press).
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Cosker, K;
Mallach, A;
Limaye, J;
Piers, TM;
Staddon, J;
Neame, SJ;
Hardy, J;
(2021)
Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Scientific Reports
, 11
(1)
, Article 13316. 10.1038/s41598-021-91207-1.
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Forabosco, P;
Ramasamy, A;
Trabzuni, D;
Walker, R;
Smith, C;
Bras, J;
Levine, AP;
... Ryten, M; + view all
(2013)
Insights into TREM2 biology by network analysis of human brain gene expression data.
Neurobiol Aging
, 34
(12)
pp. 2699-2714.
10.1016/j.neurobiolaging.2013.05.001.
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Garcia-Reitboeck, P;
Phillips, A;
Piers, TM;
Villegas-Llerena, C;
Butler, M;
Mallach, A;
Rodrigues, C;
... Pocock, JM; + view all
(2018)
Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Cell Reports
, 24
(9)
pp. 2300-2311.
10.1016/j.celrep.2018.07.094.
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Hodges, Angela K;
Piers, Thomas M;
Collier, David;
Cousins, Oliver;
Pocock, Jennifer M;
(2021)
Pathways linking Alzheimer’s disease risk genes expressed highly in microglia.
Neuroimmunology and Neuroinflammation
, 8
pp. 245-268.
10.20517/2347-8659.2020.60.
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Hooper, C;
Sainz-Fuertes, R;
Lynham, S;
Hye, A;
Killick, R;
Warley, A;
Bolondi, C;
... Lovestone, S; + view all
(2020)
Correction to: Wnt3a induces exosome secretion from primary cultured rat microglia.
[Corrigendum].
BMC Neuroscience
, 21
(1)
, Article 10. 10.1186/s12868-020-0558-9.
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Jiwrajka, M;
Phillips, A;
Butler, M;
Rossi, M;
Pocock, JM;
(2016)
The Plant-Derived Chalcone 2,2',5'-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia.
Oxidative Medicine and Cellular Longevity
, 2016
, Article 6301712. 10.1155/2016/6301712.
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Lange, J;
Haslett, LJ;
Lloyd-Evans, E;
Pocock, JM;
Sands, MS;
Williams, BP;
Cooper, JD;
(2018)
Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis.
Acta Neuropathologica Communications
, 6
, Article 74. 10.1186/s40478-018-0575-4.
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Liu, W;
Taso, O;
Wang, R;
Bayram, S;
Graham, AC;
Garcia-Reitboeck, P;
Mallach, A;
... Salih, DA; + view all
(2020)
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
Human Molecular Genetics
10.1093/hmg/ddaa209.
(In press).
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Magusali, N;
Graham, AC;
Piers, TM;
Panichnantakul, P;
Yaman, U;
Shoai, M;
Reynolds, RH;
... Salih, DA; + view all
(2021)
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Brain
10.1093/brain/awab337.
(In press).
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Mallach, A;
Gobom, J;
Arber, C;
Piers, TM;
Hardy, J;
Wray, S;
Zetterberg, H;
(2021)
Differential stimulation of pluripotent stem cell-derived human microglia leads to exosomal proteomic changes affecting neurons.
Cells
, 10
(11)
, Article 2866. 10.3390/cells10112866.
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Mallach, A;
Gobom, J;
Zetterberg, H;
Hardy, J;
Piers, TM;
Wray, S;
Pocock, JM;
(2021)
The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.
Brain Communications
, 3
(2)
, Article fcab009. 10.1093/braincomms/fcab009.
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Nazish, I;
Arber, C;
Piers, TM;
Warner, TT;
Hardy, JA;
Lewis, PA;
Pocock, JM;
(2021)
Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.
Neurochemistry International
, 147
, Article 105070. 10.1016/j.neuint.2021.105070.
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Nazish, Iqra;
Mamais, Adamantios;
Mallach, Anna;
Bettencourt, Conceisao;
Kaganovich, Alice;
Warner, Thomas;
Hardy, John;
... Bandopadhyay, Rina; + view all
(2024)
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Cells
, 13
(1)
, Article 53. 10.3390/cells13010053.
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O'Regan, GC;
Farag, SH;
Casey, CS;
Wood-Kaczmar, A;
Pocock, JM;
Tabrizi, SJ;
Andre, R;
(2021)
Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species.
Journal of Neuroinflammation
, 18
, Article 94. 10.1186/s12974-021-02147-6.
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Piers, TM;
Cosker, K;
Mallach, A;
Johnson, GT;
Guerreiro, R;
Hardy, J;
Pocock, JM;
(2019)
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
FASEB Journal
10.1096/fj.201902447R.
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Piers, TM;
East, E;
Villegas-Llerena, C;
Sevastou, IG;
Matarin, M;
Hardy, J;
Pocock, JM;
(2018)
Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity.
Frontiers in Cellular Neuroscience
, 12
, Article 404. 10.3389/fncel.2018.00404.
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Pocock, Jennifer;
Vasilopoulou, Foteini;
Svensson, Elina;
Cosker, Katharina;
(2024)
Microglia and TREM2.
Neuropharmacology
, 257
, Article 110020. 10.1016/j.neuropharm.2024.110020.
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Pocock, JM;
Piers, TM;
(2018)
Modelling microglial function with induced pluripotent stem cells: an update.
Nature Reviews Neuroscience
, 19
pp. 445-452.
10.1038/s41583-018-0030-3.
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Popescu, Alma S;
Butler, Claire A;
Allendorf, David H;
Piers, Thomas M;
Mallach, Anna;
Roewe, Julian;
Reinhardt, Peter;
... Brown, Guy C; + view all
(2022)
Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
GLIA
10.1002/glia.24318.
(In press).
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Russell, CL;
Heslegrave, A;
Mitra, V;
Zetterberg, H;
Pocock, JM;
Ward, MA;
Pike, I;
(2017)
Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study.
Rapid Communications in Mass Spectrometry
, 31
(2)
pp. 153-159.
10.1002/rcm.7777.
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Sadeghian, M;
Mullali, G;
Pocock, JM;
Piers, T;
Roach, A;
Smith, KJ;
(2016)
Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease.
Neuropathology and Applied Neurobiology
, 42
(5)
pp. 423-435.
10.1111/nan.12263.
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Taylor, D.L.;
Diemel, L.T.;
Pocock, J.M.;
(2003)
Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity.
The Journal of Neuroscience
, 23
(6)
pp. 2150-2160.
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Taylor, DL;
Jones, F;
Kubota, ESFCS;
Pocock, JM;
(2005)
Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand.
J NEUROSCI
, 25
(11)
2952 - 2964.
10.1523/JNEUROSCI.4456-04.2005.
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Wei, Jingzhang;
Arber, Charles;
Wray, Selina;
Hardy, John;
Piers, Thomas M;
Pocock, Jennifer M;
(2022)
Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model.
Glia
10.1002/glia.24325.
(In press).
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Xiang, X;
Piers, TM;
Wefers, B;
Zhu, K;
Mallach, A;
Brunner, B;
Kleinberger, G;
... Haass, C; + view all
(2018)
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Molecular Neurodegeneration
, 13
(1)
, Article 49. 10.1186/s13024-018-0280-6.
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Working / discussion paper
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Liu, W;
Taso, O;
Wang, R;
Garcia-Reitboeck, P;
Andrews, WD;
Piers, TM;
Pocock, JM;
... Salih, D; + view all
(2018)
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
bioRxiv
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Thesis
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Crehan, H;
(2014)
Complement receptor 1 in microglia: implications for Alzheimer's disease.
Doctoral thesis , UCL (University College London).
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Dobson, L;
(2017)
Investigation into pathological neuronal-myeloid cell interactions and rescue of hyper-reactive immune responses in Huntington’s disease.
Doctoral thesis , UCL (University College London).
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Jebelli, JD;
(2014)
P53 Signalling in microglia: implications for neurodegeneration (Pocock, JM, Trans.).
Doctoral thesis , UCL (University College London).
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