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Modelling microglial function with induced pluripotent stem cells: an update

Pocock, JM; Piers, TM; (2018) Modelling microglial function with induced pluripotent stem cells: an update. Nature Reviews Neuroscience , 19 pp. 445-452. 10.1038/s41583-018-0030-3. Green open access

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Abstract

It is becoming increasingly apparent that microglia, the immune cells of the CNS, and their peripheral counterparts, macrophages, have a major role in normal physiology and pathology. Recent technological advances in the production of particular cell types from induced pluripotent stem cells have led to an interest in applying this methodology to the production of microglia. Here, we discuss recent advances in this area and describe how they will aid our future understanding of microglia.

Type: Article
Title: Modelling microglial function with induced pluripotent stem cells: an update
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41583-018-0030-3
Publisher version: http://dx.doi.org/10.1038/s41583-018-0030-3
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Induced pluripotent stem cells, Microglia, Microglial cells, Neurological models
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10054247
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