Browse by UCL people
Group by: Type | Date
Number of items: 50.
Article
Bolik-Coulon, N;
Sever, AIM;
Harkness, RW;
Aramini, JM;
Toyama, Y;
Hansen, DF;
Kay, LE;
(2023)
Less is more: A simple methyl-TROSY based pulse scheme offers improved sensitivity in applications to high molecular weight complexes.
Journal of Magnetic Resonance
, 346
, Article 107326. 10.1016/j.jmr.2022.107326.
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Bolik-Coulon, Nicolas;
Hansen, D Flemming;
Kay, Lewis E;
(2022)
Optimizing frequency sampling in CEST experiments.
Journal of Biomolecular NMR
, 76
(5-6)
pp. 167-183.
10.1007/s10858-022-00403-2.
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Dagil, L;
Troelsen, KS;
Bolt, G;
Thim, L;
Wu, B;
Zhao, X;
Tuddenham, EGD;
... Hansen, DF; + view all
(2019)
Interaction Between the a3 Region of Factor VIII and the TIL'E’ Domains of the von Willebrand Factor.
Biophysical Journal
, 117
(3)
pp. 479-489.
10.1016/j.bpj.2019.07.007.
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Darling, William TP;
Wieske, Lianne HE;
Cook, Declan T;
Aliev, Abil E;
Caron, Laurent;
Humphrys, Emily J;
Figueiredo, Angelo Miguel;
... Tabor, Alethea B; + view all
(2024)
The Influence of Disulfide, Thioacetal and Lanthionine-Bridges on the Conformation of a Macrocyclic Peptide.
xChemistry – A European Journal
, 30
(50)
, Article e202401654. 10.1002/chem.202401654.
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Dickman, R;
Danelius, E;
Mitchell, SA;
Hansen, DF;
Erdélyi, M;
Tabor, AB;
(2019)
A Chemical Biology Approach to Understanding Molecular Recognition of Lipid II by Nisin(1-12): Synthesis and NMR Ensemble Analysis of Nisin(1-12) and Analogues.
Chemistry
10.1002/chem.201902814.
(In press).
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Dickman, R;
Mitchell, SA;
Figueiredo, AM;
Hansen, DF;
Tabor, AB;
(2019)
Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B.
The Journal of Organic Chemistry
, 84
(18)
pp. 11493-11512.
10.1021/acs.joc.9b01253.
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Gerecht, K;
Figueiredo, AM;
Hansen, DF;
(2017)
Determining rotational dynamics of the guanidino group of arginine side chains in proteins by carbon-detected NMR.
Chemical Communications
, 53
pp. 10062-10065.
10.1039/c7cc04821a.
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Gopalan, AB;
Hansen, DF;
Vallurupalli, P;
(2018)
CPMG Experiments for Protein Minor Conformer Structure Determination.
Methods in Molecular Biology
, 1688
pp. 223-242.
10.1007/978-1-4939-7386-6_11.
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Greenwood, SOR;
Chan, AWE;
Hansen, DF;
Marson, CM;
(2020)
Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit.
Bioorganic & Medicinal Chemistry Letters
, 30
(5)
, Article 126926. 10.1016/j.bmcl.2019.126926.
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Hansen, DF;
(2019)
Using Deep Neural Networks to Reconstruct Non-uniformly Sampled NMR Spectra.
Journal of Biomolecular NMR
10.1007/s10858-019-00265-1.
(In press).
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Hansen, DF;
(2017)
Measurement of (15)N longitudinal relaxation rates in (15)NH4(+) spin systems to characterise rotational correlation times and chemical exchange.
Journal of Magnetic Resonance
, 279
pp. 91-98.
10.1016/j.jmr.2017.01.015.
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Heller, Gabriella T;
Shukla, Vaibhav Kumar;
Figueiredo, Angelo Miguel;
Hansen, D Flemming;
(2024)
Picosecond Dynamics of a Small Molecule in Its Bound State with an Intrinsically Disordered Protein.
Journal of the American Chemical Society
10.1021/jacs.3c11614.
(In press).
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Juen, MA;
Wunderlich, CH;
Nußbaumer, F;
Tollinger, M;
Kontaxis, G;
Konrat, R;
Hansen, DF;
(2016)
Excited States of Nucleic Acids Probed by Proton Relaxation Dispersion NMR Spectroscopy.
Angewandte Chemie
, 128
(39)
pp. 12187-12191.
10.1002/ange.201605870.
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Juen, MA;
Wunderlich, CH;
Nussbaumer, F;
Tollinger, M;
Kontaxis, G;
Konrat, R;
Hansen, DF;
(2016)
Excited States of Nucleic Acids Probed by Proton Relaxation Dispersion NMR Spectroscopy.
Angewandte Chemie International Edition
, 55
(39)
pp. 12008-12012.
10.1002/anie.201605870.
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Karunanithy, G;
Mackenzie, HW;
Hansen, DF;
(2021)
Virtual Homonuclear Decoupling in Direct Detection Nuclear Magnetic Resonance Experiments using Deep Neural Networks.
Journal of the American Chemical Society
, 143
(41)
pp. 16935-16942.
10.1021/jacs.1c04010.
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Karunanithy, G;
Shukla, V;
Hansen, DF;
(2021)
Methodological Advancements for Characterising Protein Side Chains by NMR Spectroscopy.
Current Opinion in Structural Biology
, 70
pp. 61-69.
10.1016/j.sbi.2021.04.002.
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Karunanithy, Gogulan;
Yuwen, Tairan;
Kay, Lewis E;
Hansen, D Flemming;
(2022)
Towards autonomous analysis of chemical exchange saturation transfer experiments using deep neural networks.
Journal of Biomolecular NMR
10.1007/s10858-022-00395-z.
(In press).
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Karunanithy, G;
Hansen, DF;
(2021)
FID-Net: A versatile deep neural network architecture for NMR spectral reconstruction and virtual decoupling.
Journal of Biomolecular NMR
10.1007/s10858-021-00366-w.
(In press).
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Karunanithy, G;
Reinstein, J;
Hansen, DF;
(2020)
Multi-Quantum Chemical Exchange Saturation Transfer NMR to Quantify Symmetrical Exchange: Application to Rotational Dynamics of the Guanidinium Group in Arginine Side Chains.
The Journal of Physical Chemistry Letters
, 11
(14)
pp. 5649-5654.
10.1021/acs.jpclett.0c01322.
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Kunze, MB;
Wright, DW;
Werbeck, ND;
Kirkpatrick, J;
Coveney, PV;
Hansen, DF;
(2013)
Loop interactions and dynamics tune the enzymatic activity of the human histone deacetylase 8.
J Am Chem Soc
, 135
(47)
17862 - 17868.
10.1021/ja408184x.
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Kuzmanic, A;
Pritchard, RB;
Hansen, DF;
Gervasio, FL;
(2019)
Importance of the Force Field Choice in Capturing Functionally Relevant Dynamics in the von Willebrand Factor.
The Journal of Physical Chemistry Letters
, 10
(8)
pp. 1928-1934.
10.1021/acs.jpclett.9b00517.
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Mackenzie, HW;
Flemming Hansen, D;
(2019)
Arginine Side-Chain Hydrogen Exchange: Quantifying Arginine Side-Chain Interactions in Solution.
ChemPhysChem
, 20
(2)
, Article Special Issue: BioNMR Spectroscopy. 10.1002/cphc.201800598.
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Mackenzie, HW;
Hansen, DF;
(2017)
A 13C-detected 15N double-quantum NMR experiment to probe arginine side-chain guanidinium 15Nη chemical shifts.
J Biomol NMR
, 69
(3)
pp. 123-132.
10.1007/s10858-017-0137-2.
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Malevanets, A;
Chong, PA;
Hansen, DF;
Rizk, P;
Sun, Y;
Lin, H;
Muhandiram, R;
... Wodak, SJ; + view all
(2017)
Interplay of buried histidine protonation and protein stability in prion misfolding.
Scientific Reports
, 7
, Article 882. 10.1038/s41598-017-00954-7.
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Mollner, TA;
Isenegger, PG;
Josephson, B;
Buchanan, C;
Lercher, L;
Oehlrich, D;
Hansen, DF;
... Davis, BG; + view all
(2021)
Post-translational insertion of boron in proteins to probe and modulate function.
Nature Chemical Biology
10.1038/s41589-021-00883-7.
(In press).
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Pettitt, AJ;
Shukla, VK;
Figueiredo, AM;
Newton, LS;
McCarthy, S;
Tabor, AB;
Heller, GT;
... Hansen, DF; + view all
(2024)
An integrative characterization of proline cis and trans conformers in a disordered peptide.
Biophysical Journal
, 123
(21)
pp. 3798-3811.
10.1016/j.bpj.2024.09.028.
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Pritchard, RB;
Hansen, DF;
(2019)
Characterising side chains in large proteins by protonless 13C-detected NMR spectroscopy.
Nature Communications
, 10
(1)
, Article 1747. 10.1038/s41467-019-09743-4.
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Puglisi, R;
Karunanithy, G;
Hansen, DF;
Pastore, A;
Temussi, PA;
(2021)
The anatomy of unfolding of Yfh1 is revealed by site-specific fold stability analysis measured by 2D NMR spectroscopy.
Communications Chemistry
, 4
(1)
, Article 127. 10.1038/s42004-021-00566-3.
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Pustovalova, Y;
Delaglio, F;
Craft, DL;
Arthanari, H;
Bax, A;
Billeter, M;
Bostock, MJ;
... Schuyler, AD; + view all
(2021)
NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR.
Magnetic Resonance
, 2
(2)
pp. 843-861.
10.5194/mr-2-843-2021.
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Schneider, R;
Maurin, D;
Communie, G;
Kragelj, J;
Hansen, DF;
Ruigrok, RW;
Jensen, MR;
(2015)
Visualizing the molecular recognition trajectory of an intrinsically disordered protein using multinuclear relaxation dispersion NMR.
Journal of the American Chemical Society
, 137
(3)
pp. 1220-1229.
10.1021/ja511066q.
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Shukla, Vaibhav Kumar;
Heller, Gabriella T;
Hansen, D Flemming;
(2023)
Biomolecular NMR spectroscopy in the era of artificial intelligence.
Structure
10.1016/j.str.2023.09.011.
(In press).
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Shukla, Vaibhav Kumar;
Siemons, Lucas;
Hansen, D Flemming;
(2023)
Intrinsic structural dynamics dictate enzymatic activity and inhibition.
Proceedings of the National Academy of Sciences
, 120
(41)
, Article e2310910120. 10.1073/pnas.2310910120.
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Shukla, VK;
Siemons, L;
Gervasio, FL;
Hansen, DF;
(2021)
Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8.
Chemical Science
10.1039/d1sc01929e.
(In press).
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Siemons, L;
Mackenzie, HW;
Shukla, VK;
Hansen, DF;
(2019)
Intra-residue methyl-methyl correlations for valine and leucine residues in large proteins from a 3D-HMBC-HMQC experiment.
Journal of Biomolecular NMR
10.1007/s10858-019-00287-9.
(In press).
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Siemons, L;
Uluca-Yazgi, B;
Pritchard, RB;
McCarthy, S;
Heise, H;
Hansen, DF;
(2019)
Determining isoleucine side-chain rotamer-sampling in proteins from {13}^C chemical shift.
Chemical Communications
10.1039/c9cc06496f.
(In press).
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Soloviev, Zoja;
Bullock, Joshua MA;
James, Juliette MB;
Sauerwein, Andrea C;
Nettleship, Joanne E;
Owens, Raymond J;
Hansen, D Flemming;
... Thalassinos, Konstantinos; + view all
(2022)
Structural mass spectrometry decodes domain interaction and dynamics of the full-length Human Histone Deacetylase 2.
Biochimica et Biophysica Acta - Proteins and Proteomics
, 1870
(3)
, Article 140759. 10.1016/j.bbapap.2022.140759.
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Song, Y;
Dagil, L;
Fairall, L;
Robertson, N;
Wu, M;
Ragan, TJ;
Savva, CG;
... Schwabe, JWR; + view all
(2020)
Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.
Cell Reports
, 30
(8)
2699-2711.e8.
10.1016/j.celrep.2020.01.091.
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Werbeck, ND;
Hansen, DF;
(2014)
Heteronuclear transverse and longitudinal relaxation in AX4 spin systems: Application to (15)N relaxations in (15)NH4(+).
J Magn Reson
, 246C
136 - 148.
10.1016/j.jmr.2014.06.010.
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Werbeck, ND;
Kirkpatrick, J;
Hansen, DF;
(2013)
Probing arginine side-chains and their dynamics with carbon-detected NMR spectroscopy: application to the 42 kDa human histone deacetylase 8 at high pH.
Angew Chem Int Ed Engl
, 52
(11)
3145 - 3147.
10.1002/anie.201209385.
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Werbeck, ND;
Kirkpatrick, J;
Reinstein, J;
Hansen, DF;
(2014)
Using (15) N-Ammonium to Characterise and Map Potassium Binding Sites in Proteins by NMR Spectroscopy.
Chembiochem
, 15
(4)
pp. 543-548.
10.1002/cbic.201300700.
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Werbeck, ND;
Shukla, VK;
Kunze, MBA;
Yalinca, H;
Pritchard, RB;
Siemons, L;
Mondal, S;
... Hansen, DF; + view all
(2020)
A distal regulatory region of a class I human histone deacetylase.
Nature Communications
, 11
(1)
, Article 3841. 10.1038/s41467-020-17610-w.
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Zeymer, C;
Werbeck, ND;
Zimmermann, S;
Reinstein, J;
Hansen, DF;
(2016)
Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction.
Angewandte Chemie
, 128
(38)
pp. 11705-11709.
10.1002/ange.201606238.
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Zeymer, C;
Werbeck, ND;
Zimmermann, S;
Reinstein, J;
Hansen, DF;
(2016)
Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction.
Angewandte Chemie International Edition
, 55
(38)
pp. 11533-11537.
10.1002/anie.201606238.
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Book chapter
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Sauerwein, AC;
Hansen, DF;
(2015)
Relaxation Dispersion NMR Spectroscopy.
[Book].
In: Berliner, L, (ed.)
Protein NMR: Modern Techniques and Biomedical Applications.
(pp. 75-132).
Springer: Cham, Switzerland.
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Working / discussion paper
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Karunanithy, G;
Hansen, F;
(2021)
FID-Net: A Versatile Deep Neural Network Architecture for NMR Spectral Reconstruction and Virtual Decoupling.
ChemRxiv: Cambridge, UK.
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Karunanithy, G;
Mackenzie, H;
Hansen, F;
(2021)
Virtual Homonuclear Decoupling in Direct Detection NMR Experiments using Deep Neural Networks.
ChemRxiv: Cambridge, UK.
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Thesis
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O'Brien, Harrison Edward Rowe;
(2021)
The structure, dynamics and interactions of the von Willebrand factor C3 domain.
Doctoral thesis (Ph.D), UCL (University College London).
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Shiltagh, N;
(2013)
Solution structure of the factor VIII binding region on von Willebrand factor.
Doctoral thesis , UCL (University College London).
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Siemons, Lucas;
(2020)
Characterising side-chain motions in proteins by Nuclear Magnetic Resonance and Molecular Dynamics to report on function and regulation.
Doctoral thesis (Ph.D), UCL (University College London).
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Soloviev, Z;
(2017)
Structural mass spectrometry studies of proteins and protein complexes involved in the regulation of gene expression.
Doctoral thesis , UCL (University College London).
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