Browse by UCL people
Group by: Type | Date
Number of items: 34.
2023
Wu, Yiming;
Gettler, Kyle;
Kars, Meltem Ece;
Giri, Mamta;
Li, Dalin;
Bayrak, Cigdem Sevim;
Zhang, Peng;
... Itan, Yuval; + view all
(2023)
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients.
Nature Communications
, 14
, Article 2256. 10.1038/s41467-023-37849-3.
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2021
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Pasvol, TJ;
Bloom, S;
Segal, AW;
Rait, G;
Horsfall, L;
(2021)
Use of contraceptives and risk of inflammatory bowel disease: A nested case–control study.
Alimentary Pharmacology and Therapeutics
10.1111/apt.16647.
(In press).
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2019
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Foote, JR;
Patel, AA;
Yana, S;
Segal, AW;
(2019)
Variations in the Phagosomal Environment of Human Neutrophils and Mononuclear Phagocyte Subsets.
Frontiers in Immunology
, 10
, Article 188. 10.3389/fimmu.2019.00188.
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Pasvol, TJ;
Horsfall, L;
Bloom, S;
Segal, AW;
Sabin, C;
Field, N;
Winston, A;
(2019)
Inflammatory Bowel Disease in Uk Primary Care: Sociodemographic Trends in Incidence.
Presented at: Digestive Disease Week (DDW), San Diego, CA, USA.
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Pasvol, TJ;
Horsfall, L;
Bloom, S;
Segal, AW;
Sabin, C;
Field, N;
Winston, A;
(2019)
Inflammatory Bowel Disease in Uk Primary Care: Temporal Trends in Epidemiology During the Early 21st Century.
Presented at: Digestive Disease Week (DDW), San Diego, CA, USA.
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Rivas, MA;
Avila, BE;
Koskela, J;
Huang, H;
Stevens, C;
Pirinen, M;
Haritunians, T;
... Daly, MJ; + view all
(2019)
Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
[Corrigendum].
PLoS Genetics
, 15
(5)
, Article e1008190. 10.1371/journal.pgen.1008190.
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2018
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Frampton, M;
Schiff, E;
Pontikos, N;
Segal, A;
Levine, A;
(2018)
Seqfam: A python package for analysis of Next Generation Sequencing DNA data in families [version 1].
F1000Research
, 7
, Article 281. 10.12688/f1000research.13930.1.
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Hui, KY;
Fernandez-Hernandez, H;
Hu, J;
Schaffner, A;
Pankratz, N;
Hsu, N-Y;
Chuang, L-S;
... Peter, I; + view all
(2018)
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease.
Science Translational Medicine
, 10
(423)
, Article eaai7795. 10.1126/scitranslmed.aai7795.
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Normand, S;
Waldschmitt, N;
Neerincx, A;
Martinez-Torres, RJ;
Chauvin, C;
Couturier-Maillard, A;
Boulard, O;
... Chamaillard, M; + view all
(2018)
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.
Nature Communications
, 9
(1)
, Article 5338. 10.1038/s41467-018-07750-5.
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Rivas, MA;
Avila, BE;
Koskela, J;
Huang, H;
Stevens, C;
Pirinen, M;
Haritunians, T;
... Daly, MJ; + view all
(2018)
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
PLoS Genetics
, 14
(5)
, Article e1007329. 10.1371/journal.pgen.1007329.
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Schiff, ER;
Frampton, M;
Ben-Yosef, N;
Avila, BE;
Semplici, F;
Pontikos, N;
Bloom, SL;
... Levine, AP; + view all
(2018)
Rare coding variant analysis in a large cohort of Ashkenazi Jewish families with inflammatory bowel disease.
Human Genetics
, 137
(9)
pp. 723-734.
10.1007/s00439-018-1927-7.
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Schiff, ER;
Frampton, M;
Semplici, F;
Bloom, SL;
McCartney, SA;
Vega, R;
Lovat, LB;
... Levine, AP; + view all
(2018)
A New Look at Familial Risk of Inflammatory Bowel Disease in the Ashkenazi Jewish Population.
Digestive Diseases and Sciences
, 63
(11)
pp. 3049-3057.
10.1007/s10620-018-5219-9.
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Segal, AW;
(2018)
The role of neutrophils in the pathogenesis of Crohn's disease.
European Journal of Clinical Investigation
10.1111/eci.12983.
(In press).
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Vinayaga-Pavan, M;
Frampton, M;
Pontikos, N;
Levine, AP;
Smith, PJ;
Jonasson, JG;
Björnsson, ES;
... Smith, AM; + view all
(2018)
Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis.
Inflammatory Bowel Diseases
, 25
(2)
pp. 317-327.
10.1093/ibd/izy350.
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2017
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Behe, P;
Foote, JR;
Levine, AP;
Platt, CD;
Chou, J;
Benavides, F;
Geha, RS;
(2017)
The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils.
Frontiers in Pharmacology
, 8
, Article 262. 10.3389/fphar.2017.00262.
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Foote, JR;
Behe, P;
Frampton, M;
Levine, AP;
Segal, AW;
(2017)
Corrigendum: An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.
[Corrigendum].
Frontiers In Pharmacology
, 8
, Article 728. 10.3389/fphar.2017.00728.
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Foote, JR;
Behe, P;
Frampton, M;
Levine, AP;
Segal, AW;
(2017)
An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.
Frontiers in Pharmacology
, 8
, Article 94. 10.3389/fphar.2017.00094.
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Foote, JR;
Levine, AP;
Behe, P;
Duchen, MR;
Segal, AW;
(2017)
Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator.
Journal of Visualized Experiments
(122)
, Article e55107. 10.3791/55107.
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Shaw, L;
Ribeiro, ALR;
Levine, AP;
Pontikos, N;
Balloux, F;
Segal, AW;
Roberts, AP;
(2017)
The Human Salivary Microbiome Is Shaped by Shared Environment Rather than Genetics: Evidence from a Large Family of Closely Related Individuals.
MBio
, 8
(5)
, Article e01237-17. 10.1128/mBio.01237-17.
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2016
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Chuang, LS;
Villaverde, N;
Hui, KY;
Mortha, A;
Rahman, A;
Levine, AP;
Haritunians, T;
... Cho, JH; + view all
(2016)
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GMCSF.
Gastroenterology
, 151
(4)
710-723.e2.
10.1053/j.gastro.2016.06.045.
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Levine, AP;
Pontikos, N;
Schiff, ER;
Jostins, L;
Speed, D;
NIDDK Inflammatory Bowel Disease Genetics Consortium, .;
Lovat, LB;
... Segal, AW; + view all
(2016)
Genetic Complexity of Crohn’s Disease in Two Large Ashkenazi Jewish Families.
Gastroenterology
, 151
(4)
pp. 698-709.
10.1053/j.gastro.2016.06.040.
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O'Shea, NR;
Chew, TS;
Dunne, J;
Marnane, R;
Nedjat-Shokouhi, B;
Smith, PJ;
Bloom, SL;
... Segal, AW; + view all
(2016)
Critical role of the disintegrin metalloprotease ADAM-like Decysin-1 (ADAMDEC1) for intestinal immunity and inflammation.
Journal of Crohn's and Colitis
, 10
(12)
pp. 1417-1427.
10.1093/ecco-jcc/jjw111.
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Segal, AW;
(2016)
Making sense of the cause of Crohn's - a new look at an old disease.
F1000Research
, 5
, Article 2510. 10.12688/f1000research.9699.2.
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Segal, AW;
(2016)
NADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humans.
Open Biology
, 6
(5)
, Article 160028. 10.1098/rsob.160028.
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2015
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Chew, TS;
O'Shea, NR;
Sewell, GW;
Oehlers, SH;
Mulvey, CM;
Crosier, PS;
Godovac-Zimmermann, J;
... Segal, AW; + view all
(2015)
Optineurin deficiency contributes to impaired cytokine secretion and neutrophil recruitment in bacteria driven colitis.
Disease Models & Mechanisms
, 8
(8)
817- 829.
10.1242/dmm.020362.
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Levine, AP;
Connor, TM;
Oygar, DD;
Neild, GH;
Segal, AW;
Maxwell, PH;
Gale, DP;
(2015)
Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.
BMC Genomics
, 16
, Article 163. 10.1186/s12864-015-1360-4.
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Levine, AP;
Connor, TM;
Oygar, DD;
Neild, GH;
Segal, AW;
Maxwell, PH;
Gale, DP;
(2015)
Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.
BMC Genomics
, 16
, Article 163. 10.1186/s12864-015-1360-4.
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Levine, AP;
Duchen, MR;
de Villiers, S;
Rich, PR;
Segal, AW;
(2015)
Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity.
PLoS One
, 10
(4)
, Article e0125906. 10.1371/journal.pone.0125906.
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Smith, AM;
Sewell, GW;
Levine, AP;
Chew, TS;
Dunne, J;
O'Shea, NR;
Smith, PJ;
... Segal, AW; + view all
(2015)
Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients.
Immunology
, 144
(1)
45 - 55.
10.1111/imm.12338.
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2013
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Chen, Y;
Ogundare, M;
Williams, CM;
Wang, Y;
Wang, Y;
Sewell, GW;
Smith, PJ;
... Griffiths, WJ; + view all
(2013)
Shotgun cholanomics of ileal fluid.
Biochimie
, 95
(3)
461 - 463.
10.1016/j.biochi.2012.09.004.
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2012
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Sewell, GW;
Hannun, YA;
Han, X;
Koster, G;
Bielawski, J;
Goss, V;
Smith, PJ;
... Segal, AW; + view all
(2012)
Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition.
Int J Biochem Cell Biol
, 44
(11)
1839 - 1846.
10.1016/j.biocel.2012.06.016.
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Sewell, GW;
Rahman, FZ;
Levine, AP;
Jostins, L;
Smith, PJ;
Walker, AP;
Bloom, SL;
... Smith, AM; + view all
(2012)
Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci.
Inflammatory Bowel Diseases
, 18
(11)
2120 - 2127.
10.1002/ibd.22952.
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2010
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Rahman, FZ;
Smith, AM;
Hayee, B;
Marks, DJB;
Bloom, SL;
Segal, AW;
(2010)
Delayed Resolution of Acute Inflammation in Ulcerative Colitis Is Associated with Elevated Cytokine Release Downstream of TLR4.
PLOS ONE
, 5
(3)
, Article e9891. 10.1371/journal.pone.0009891.
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2009
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Palmer, CD;
Rahman, FZ;
Sewell, GW;
Ahmed, A;
Ashcroft, M;
Bloom, SL;
Segal, AW;
(2009)
Diminished Macrophage Apoptosis and Reactive Oxygen Species Generation after Phorbol Ester Stimulation in Crohn's Disease.
PLoS ONE
, 4
(11)
, Article e7787. 10.1371/journal.pone.0007787.
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