Browse by UCL people
Group by: Type | Date
Number of items: 41.
Article
Abdullah Alfayez, A;
Kunz, H;
Grace Lai, A;
(2021)
Predicting the risk of cancer in adults using supervised machine learning: a scoping review.
BMJ Open
, 11
(9)
, Article e047755. 10.1136/bmjopen-2020-047755.
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Banerjee, A;
Pasea, L;
Manohar, S;
Lai, AG;
Hemingway, E;
Sofer, I;
Katsoulis, M;
... and members of the Health Data Research UK COVID-19 Patient and; + view all
(2021)
'What is the risk to me from COVID-19?': Public involvement in providing mortality risk information for people with 'high-risk' conditions for COVID-19 (OurRisk.CoV).
Clinical Medicine Journal
, 21
(6)
e620-e628.
10.7861/clinmed.2021-0386.
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Banerjee, A;
Chen, S;
Pasea, L;
Lai, AG;
Katsoulis, M;
Denaxas, S;
Nafilyan, V;
... Hemingway, H; + view all
(2021)
Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic.
European Journal of Preventive Cardiology
10.1093/eurjpc/zwaa155.
(In press).
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Banerjee, A;
Katsoulis, M;
Lai, AG;
Pasea, L;
Treibel, TA;
Manisty, C;
Denaxas, S;
... Moon, JC; + view all
(2020)
Clinical academic research in the time of Corona: A simulation study in England and a call for action.
PLoS One
, 15
(8)
, Article e0237298. 10.1371/journal.pone.0237298.
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Boecker, M;
Lai, AG;
(2020)
Could personalised risk prediction for type 2 diabetes using polygenic risk scores direct prevention, enhance diagnostics, or improve treatment? [version 1; peer review: awaiting peer review].
Wellcome Open Research
, 5
p. 206.
10.12688/wellcomeopenres.16251.1.
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Chang, Wai Hoong;
Foster, Graham R;
Kelly, Deirdre A;
Lai, Alvina G;
(2022)
Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease.
BJPsych Open
, 8
(5)
, Article e146. 10.1192/bjo.2022.550.
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Chang, Wai Hoong;
Lai, Alvina G;
(2024)
Pan-cancer analyses of the associations between 109 pre-existing conditions and cancer treatment patterns across 19 adult cancers.
Scientific Reports
, 14
(1)
, Article 464. 10.1038/s41598-024-51161-0.
(In press).
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Chang, Wai Hoong;
Lai, Alvina G;
(2022)
Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers.
Nature Medicine
10.1038/s41591-022-01740-3.
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Chang, Wai Hoong;
Neal, Richard D;
Forster, Martin D;
Lai, Alvina G;
(2023)
Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers.
Nature Communications
, 14
, Article 1484. 10.1038/s41467-023-37231-3.
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Chang, WH;
Katsoulis, M;
Tan, YY;
Mueller, SH;
Green, K;
Lai, AG;
(2021)
Late effects of cancer in children, teenagers and young adults: Population-based study on the burden of 183 conditions, in-patient and critical care admissions and years of life lost.
The Lancet Regional Health - Europe
, Article 100248. 10.1016/j.lanepe.2021.100248.
(In press).
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Chang, WH;
Mueller, SH;
Chung, S-C;
Foster, GR;
Lai, AG;
(2022)
Increased burden of cardiovascular disease in people with liver disease: unequal geographical variations, risk factors and excess years of life lost.
Journal of Translational Medicine
, 20
(1)
, Article 2. 10.1186/s12967-021-03210-9.
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Chang, WH;
Mueller, SH;
Tan, YY;
Lai, AG;
(2021)
Antithrombotic therapy in patients with liver disease: population-based insights on variations in prescribing trends, adherence, persistence and impact on stroke and bleeding.
The Lancet Regional Health - Europe
, Article 100222. 10.1016/j.lanepe.2021.100222.
(In press).
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Chang, WH;
Forde, D;
Lai, AG;
(2019)
Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance.
Cancer Communications
, 39
, Article 23. 10.1186/s40880-019-0369-5.
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Chang, WH;
Forde, D;
Lai, AG;
(2019)
A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers.
Journal of Translational Medicine
, 17
, Article 14. 10.1186/s12967-019-1775-9.
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Chang, WH;
Lai, AG;
(2020)
An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types.
BMC Cancer
, 20
(1)
, Article 773. 10.1186/s12885-020-07286-2.
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Chang, WH;
Lai, AG;
(2019)
An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components.
Molecular Medicine
, 25
(1)
, Article 46. 10.1186/s10020-019-0114-1.
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Chang, WH;
Lai, AG;
(2019)
Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion.
British Journal of Cancer
, 121
pp. 666-678.
10.1038/s41416-019-0572-9.
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Chang, WH;
Lai, AG;
(2019)
The pan-cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia.
Annals Of The New York Academy Of Sciences
, 1448
(1)
pp. 65-82.
10.1111/nyas.14170.
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Chang, WH;
Lai, AG;
(2019)
Pan-cancer genomic amplifications underlie a WNT hyperactivation phenotype associated with stem cell-like features leading to poor prognosis.
Translational Research
, 208
pp. 47-62.
10.1016/j.trsl.2019.02.008.
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Chang, WH;
Lai, AG;
(2019)
Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia.
DNA Repair
, 78
pp. 142-153.
10.1016/j.dnarep.2019.04.008.
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Chang, WH;
Lai, AG;
(2019)
Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies.
Journal of Translational Medicine
, 17
, Article 132. 10.1186/s12967-019-1880-9.
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Chung, SC;
Mueller, S;
Green, K;
Chang, WH;
Hargrave, D;
Lai, AG;
(2022)
Multimorbidity patterns and risk of hospitalisation in children: A population cohort study of 3.6 million children in England, with illustrative examples from childhood cancer survivors.
The Lancet Regional Health - Europe
, 20
, Article 100433. 10.1016/j.lanepe.2022.100433.
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Chung, Sheng-Chia;
Lai, Alvina;
Lip, Gregory YH;
Lambiase, Pier D;
Providencia, Rui;
(2023)
Impact of anti-arrhythmic drugs and catheter ablation on the survival of patients with atrial fibrillation: a population study based on 199 433 new-onset atrial fibrillation patients in the UK.
EP Europace
, 25
(2)
pp. 351-359.
10.1093/europace/euac155.
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Guo, Zhijun;
Lai, Alvina;
Thygesen, Johan;
Farrington, Joseph;
Keen, Thomas;
Li, Kezhi;
(2024)
Large Language Models for Mental Health Applications: A Systematic Review.
JMIR Mental Health
10.2196/57400.
(In press).
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Kao, D;
Lai, AG;
Stamataki, E;
Rosic, S;
Konstantinides, N;
Jarvis, E;
Di Donfrancesco, A;
... Aboobaker, A; + view all
(2016)
The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion.
eLife
, 5
, Article e20062. 10.7554/eLife.20062.
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Katsoulis, M;
De Stavola, B;
Lai, AG;
Gomes, M;
Diaz-Ordaz, K;
(2022)
The Authors Respond.
Epidemiology
, 33
(1)
e4-e5.
10.1097/EDE.0000000000001429.
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Katsoulis, M;
Lai, AG;
Diaz-Ordaz, K;
Gomes, M;
Pasea, L;
Banerjee, A;
Denaxas, S;
... Hemingway, H; + view all
(2021)
Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records.
The Lancet Diabetes and Endocrinology
, 9
(10)
pp. 681-694.
10.1016/S2213-8587(21)00207-2.
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Katsoulis, M;
Lai, AG;
Kipourou, DK;
Gomes, M;
Banerjee, A;
Denaxas, S;
Lumbers, RT;
... Diaz-Ordaz, K; + view all
(2023)
On the estimation of the effect of weight change on a health outcome using observational data, by utlilising the target trial emulation framework.
International Journal of Obesity
10.1038/s41366-023-01396-0.
(In press).
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Katsoulis, M;
Pasea, L;
Lai, AG;
Dobson, RJB;
Denaxas, S;
Hemingway, H;
Banerjee, A;
(2021)
Obesity during the COVID-19 pandemic: both cause of high risk and potential effect of lockdown? A population-based electronic health record study.
Public Health
, 191
pp. 41-47.
10.1016/j.puhe.2020.12.003.
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Katsoulis, M;
Gomes, M;
Lai, AG;
Henry, A;
Denaxas, S;
Lagiou, P;
Nafilyan, V;
... Lumbers, RT; + view all
(2020)
Estimating the effect of reduced attendance at emergency departments for suspected cardiac conditions on cardiac mortality during the COVID-19 pandemic.
Circulation: Cardiovascular Quality and Outcomes
10.1161/CIRCOUTCOMES.120.007085.
(In press).
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Katsoulis, M;
Stavola, BD;
Diaz-Ordaz, K;
Gomes, M;
Lai, A;
Lagiou, P;
Wannamethee, G;
... Hemingway, H; + view all
(2021)
Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records.
Epidemiology
, 32
(5)
pp. 744-755.
10.1097/EDE.0000000000001393.
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Kaubryte, Jurgita;
Lai, Alvina G;
(2022)
Pan-cancer prognostic genetic mutations and clinicopathological factors associated with survival outcomes: a systematic review.
npj Precision Oncology
, 6
(1)
, Article 27. 10.1038/s41698-022-00269-5.
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Lai, AG;
Chang, WH;
Parisinos, CA;
Katsoulis, M;
Blackburn, RM;
Shah, AD;
Nguyen, V;
... Hemingway, H; + view all
(2021)
An informatics consult approach for generating clinical evidence for treatment decisions.
BMC Medical Informatics and Decision Making
, 21
(1)
, Article 281. 10.1186/s12911-021-01638-z.
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Lai, AG;
Chang, WH;
Skuse, D;
(2022)
Autism and mental illness in children and young people require standardised approaches for assessment and treatment.
The Lancet Regional Health - Europe
, 16
, Article 100360. 10.1016/j.lanepe.2022.100360.
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Lai, Alvina G;
Chang, Wai Hoong;
(2022)
There is no health without mental health: Challenges ignored and lessons learned.
Clinical and Translational Medicine
, 12
(6)
, Article e897. 10.1002/ctm2.897.
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Lai, AG;
Pasea, L;
Banerjee, A;
Hall, G;
Denaxas, S;
Chang, WH;
Katsoulis, M;
... Hemingway, H; + view all
(2020)
Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study.
BMJ Open
, 10
(11)
, Article e043828. 10.1136/bmjopen-2020-043828.
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Mizani, Mehrdad A;
Dashtban, Ashkan;
Pasea, Laura;
Lai, Alvina G;
Thygesen, Johan;
Tomlinson, Chris;
Handy, Alex;
... CVD-COVID-UK Consortium; + view all
(2022)
Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19-a data-driven retrospective cohort study.
Journal of the Royal Society of Medicine
10.1177/01410768221131897.
(In press).
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Wei, Y;
Papachristou, N;
Mueller, S;
Genomics England Research Consortium;
Chang, WH;
Lai, AG;
(2021)
Application of ensemble clustering and survival tree analysis for identifying prognostic clinicogenomic features in patients with colorectal cancer from the 100,000 Genomes Project.
BMC Research Notes
, 14
(1)
, Article 385. 10.1186/s13104-021-05789-0.
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Wood, A;
Denholm, R;
Hollings, S;
Cooper, J;
Ip, S;
Walker, V;
Denaxas, S;
... CVD-COVID-UK consortium, .; + view all
(2021)
Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource.
BMJ
, 373
, Article n826. 10.1136/bmj.n826.
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Proceedings paper
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Guo, Z;
Lai, A;
Deng, Z;
Li, K;
(2024)
Evaluating the Feasibility and Acceptability of a GPT-Based Chatbot for Depression Screening: A Mixed-Methods Study.
In: Xie, X and Styles, I and Powathil, G and Ceccarelli, M, (eds.)
Artificial Intelligence in Healthcare. AIiH 2024.
(pp. pp. 249-263).
Springer: Cham, Switzerland.
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Working / discussion paper
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Katsoulis, M;
Lai, AG;
Kipourou, D-K;
Sofat, R;
Gomes, M;
Banerjee, A;
Denaxas, S;
... Diaz-Ordaz, K; + view all
(2020)
How to estimate the association between change in a risk factor and a health outcome?
ArXiv
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