Chang, Wai Hoong;
Foster, Graham R;
Kelly, Deirdre A;
Lai, Alvina G;
(2022)
Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease.
BJPsych Open
, 8
(5)
, Article e146. 10.1192/bjo.2022.550.
Preview |
Text
Lai_Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease_VoR.pdf - Published Version Download (474kB) | Preview |
Abstract
The burden of mental illness in young people with chronic liver disease is not known. In this population cohort study in England, we identified 358 individuals (aged ≤25 years) diagnosed with autoimmune hepatitis or liver disease related to cystic fibrosis and 1541 propensity-score-matched controls. By the first year of follow-up, the cumulative burden of psychiatric events in participants with liver disease was high compared with controls: anxiety disorder (6.87 per 100 individuals [95% CI 4.00-9.73] v. 2.22 [95% CI 1.37-3.07]), depression (5.10 [95% CI 2.83-7.37] v. 0.86 [95% CI 0.53-1.19]), substance misuse (10.61 [95% CI 9.50-11.73] v. 1.23 [95% CI 0.71-1.75]) and self-harm (3.09 [95% CI 1.12-5.05] v. 0.20 [95% CI 0.07-0.33]). Participants with liver disease had a 2-fold increase (OR = 1.94, 95% CI 1.45-2.58), a 2.5-fold increase (OR = 2.59, 95% CI 1.91-3.50) and 4.4-fold increase (OR = 4.44; 95% CI 3.46-5.71) in the risk of anxiety, depression and substance misuse, respectively. These findings highlight the need for effective intervention in psychiatric disorders in young people with rare liver disease.
Type: | Article |
---|---|
Title: | Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1192/bjo.2022.550 |
Publisher version: | https://doi.org/10.1192/bjo.2022.550 |
Language: | English |
Additional information: | Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
Keywords: | Mental illness, anxiety, depression, self-harm, substance misuse |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/10153101 |
Archive Staff Only
View Item |