Yuen, VM;
Li, BL;
Cheuk, DK;
Leung, MKM;
Hui, TWC;
Wong, IC;
Lam, WW;
... Irwin, MG; + view all
(2017)
A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children.
ANAESTHESIA
, 72
(10)
pp. 1191-1195.
10.1111/anae.13981.
![[thumbnail of Anesthesia Manuscript.docx]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
Anesthesia Manuscript.docx - Accepted Version Download (105kB) |
|
Text
Anesthesia Figure 2.docx - Accepted Version Download (30kB) |
Abstract
Chloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half-life. We randomly allocated 196 children to chloral hydrate syrup 50 mg.kg−1 and intranasal saline spray, or placebo syrup and intranasal dexmedetomidine spray 3 μg.kg−1, 30 min before computerised tomography studies. More children resisted or cried after drinking chloral hydrate syrup than placebo syrup, 72 of 107 (67%) vs. 42 of 87 (48%), p = 0.009, but there was no difference after intranasal saline vs. dexmedetomidine, 49 of 107 (46%) vs. 40 of 87 (46%), p = 0.98. Sedation was satisfactory in 81 of 107 (76%) children after chloral hydrate and 64 of 87 (74%) children after dexmedetomidine, p = 0.74. Of the 173 children followed up for at least 4 h after discharge, 38 of 97 (39%) had recovered normal function after chloral hydrate and 32 of 76 (42%) after dexmedetomidine, p = 0.76. Six children vomited after chloral hydrate syrup and placebo spray vs. none after placebo syrup and dexmedetomidine spray, p = 0.03.
| Type: | Article |
|---|---|
| Title: | A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/anae.13981 |
| Publisher version: | https://doi.org/10.1111/anae.13981 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Anesthesiology, Chloral Hydrate, Dexmedetomidine, Intranasal, Paediatric, Sedation, Tomography, Transthoracic Echocardiography, Pediatric-Patients, Sedation, Premedication, Electroencephalography, Pharmacokinetics, CT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1575723 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
