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The undiscovered syndrome: Macdonald Critchley's case of semantic dementia

Witoonpanich, P; Crutch, SJ; Warren, JD; Rossor, MN; (2015) The undiscovered syndrome: Macdonald Critchley's case of semantic dementia. Neurocase , 21 (4) pp. 408-412. 10.1080/13554794.2014.910307. Green open access

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Abstract

Semantic dementia is a unique clinicopathological syndrome in the frontotemporal lobar degeneration spectrum. It is characterized by progressive and relatively selective impairment of semantic memory, associated with asymmetric antero-inferior temporal lobe atrophy. Although the syndrome became widely recognized only in the 1980s, descriptions of cases with typical features of semantic dementia have been on record for over a century. Here, we draw attention to a well documented historical case of a patient with features that would have fulfilled current consensus criteria for semantic dementia, as reconstructed from the notes made by her neurologist, Macdonald Critchley, in 1938. This case raises a number of issues concerning the nosology of the semantic dementia syndrome and the potential value of archived case material.

Type: Article
Title: The undiscovered syndrome: Macdonald Critchley's case of semantic dementia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/13554794.2014.910307
Publisher version: http://dx.doi.org/10.1080/13554794.2014.910307
Language: English
Additional information: Copyright © 2014 The Author(s). Published by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: semantic dementia, Macdonald Critchley, historical, nosology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1496081
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