Polovinkin, AN;
Krylov, IB;
Druzhkov, PN;
Ivanchenko, MV;
Meyerov, IB;
Zaikin, AA;
Zolotykh, NY;
(2016)
Solving problems of clustering and classification of cancer diseases based on DNA methylation data.
Pattern Recognition and Image Analysis
, 26
(1)
pp. 176-180.
10.1134/S1054661816010181.
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Abstract
The article deals with the problem of diagnosis of oncological diseases based on the analysis of DNA methylation data using algorithms of cluster analysis and supervised learning. The groups of genes are identified, methylation patterns of which significantly change when cancer appears. High accuracy is achieved in classification of patients impacted by different cancer types and in identification if the cell taken from a certain tissue is aberrant or normal. With method of cluster analysis two cancer types are highlighted for which the hypothesis was confirmed stating that among the people affected by certain cancer types there are groups with principally different methylation pattern.
| Type: | Article |
|---|---|
| Title: | Solving problems of clustering and classification of cancer diseases based on DNA methylation data |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1134/S1054661816010181 |
| Publisher version: | http://doi.org/10.1134/S1054661816010181 |
| Language: | English |
| Additional information: | This a preprint of the Work accepted for publication in Pattern Recognition and Image Analysis, © 2016, Pleiades Publishing, Ltd. The final publication is available at Springer via http://dx.doi.org/10.1134/S1054661816010181. |
| Keywords: | Cancer; DNA methylation; classification; clustering |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1494108 |
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