Alahmadi, AA;
Samson, RS;
Gasston, D;
Pardini, M;
Friston, KJ;
D'Angelo, E;
Toosy, AT;
(2016)
Complex motor task associated with non-linear BOLD responses in cerebro-cortical areas and cerebellum.
Brain Structure and Function
, 221
(5)
pp. 2443-2458.
10.1007/s00429-015-1048-1.
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Abstract
Previous studies have used fMRI to address the relationship between grip force (GF) applied to an object and BOLD response. However, whilst the majority of these studies showed a linear relationship between GF and neural activity in the contralateral M1 and ipsilateral cerebellum, animal studies have suggested the presence of non-linear components in the GF-neural activity relationship. Here, we present a methodology for assessing non-linearities in the BOLD response to different GF levels, within primary motor as well as sensory and cognitive areas and the cerebellum. To be sensitive to complex forms, we designed a feasible grip task with five GF targets using an event-related visually guided paradigm and studied a cohort of 13 healthy volunteers. Polynomial functions of increasing order were fitted to the data.
| Type: | Article |
|---|---|
| Title: | Complex motor task associated with non-linear BOLD responses in cerebro-cortical areas and cerebellum |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00429-015-1048-1 |
| Publisher version: | http://dx.doi.org/10.1007/s00429-015-1048-1 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | fMRI; Force; MVC; Power grip; Visuomotor task |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1468229 |
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