McCormack, M;
Urban, TJ;
Shianna, KV;
Walley, N;
Pandolfo, M;
Depondt, C;
Chaila, E;
... Cavalleri, GL; + view all
(2012)
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
Pharmacogenomics
, 13
(4)
399 - 405.
10.2217/pgs.11.165.
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Abstract
An association between carbamazepine-induced hypersensitivity and HLA-A*3101 has been reported in populations of both European and Asian descent. We aimed to investigate HLA-A*3101 and other common variants across the genome as markers for cutaneous adverse drug reactions (cADRs) attributed to lamotrigine and phenytoin.
| Type: | Article |
|---|---|
| Title: | Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/pgs.11.165 |
| Publisher version: | http://dx.doi.org/10.2217/pgs.11.165 |
| Language: | English |
| Additional information: | This work is made available under a Creative Commons license. For full bibliographic citation, please refer to the version available at www.futuremedicine.com |
| Keywords: | Biomarkers, Pharmacological, Carbamazepine, Drug Hypersensitivity, Genome-Wide Association Study, HLA-A Antigens, Humans, Phenytoin, Polymorphism, Single Nucleotide, Triazines |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1343070 |
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