Ullner, E;
Zaikin, A;
Volkov, EI;
Garcia-Ojalvo, J;
(2007)
Multistability and clustering in a population of synthetic genetic oscillators via phase-repulsive cell-to-cell communication.
PHYS REV LETT
, 99
(14)
, Article 148103. 10.1103/PhysRevLett.99.148103.
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Abstract
We show that phase-repulsive coupling eliminates oscillations in a population of synthetic genetic clocks. For this, we propose an experimentally feasible synthetic genetic network that contains phase repulsively coupled repressilators with broken temporal symmetry. As the coupling strength increases, silencing of oscillations is found to occur via the appearance of an inhomogeneous limit cycle, followed by oscillation death. Two types of oscillation death are observed: For lower couplings, the cells cluster in one of two stationary states of protein expression; for larger couplings, all cells end up in a single (stationary) cellular state. Several multistable regimes are observed along this route to oscillation death.
| Type: | Article |
|---|---|
| Title: | Multistability and clustering in a population of synthetic genetic oscillators via phase-repulsive cell-to-cell communication |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1103/PhysRevLett.99.148103 |
| Publisher version: | http://dx.doi.org/10.1103/PhysRevLett.99.148103 |
| Language: | English |
| Additional information: | © 2007 The American Physical Society |
| Keywords: | DIFFERENTIATION, SYNCHRONIZATION, CIRCUITS, SYSTEM, NOISE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/116900 |
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