da Silva Castanheira, Jason;
Wiesman, Alex I;
Taylor, Margot J;
Baillet, Sylvain;
(2025)
The lifespan evolution of individualized neurophysiological traits.
Cell Reports
, 44
(12)
, Article 116657. 10.1016/j.celrep.2025.116657.
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Abstract
How do neurophysiological traits that characterize individuals evolve across the lifespan? To address this question, we analyzed task-free magnetoencephalographic recordings from over 1,000 individuals aged 4-89. We found that neurophysiological activity is more similar between individuals in childhood than in adulthood, an effect driven predominantly by arrhythmic brain activity. In contrast, periodic activity-based profiles remain reliable markers of individuality across all ages. The cortical regions most critical for determining individuality shift across neurodevelopment and aging, with sensorimotor cortices becoming increasingly prominent in adulthood. These developmental changes in neurophysiology align closely with the expression of cortical genetic systems related to ion transport and neurotransmission, suggesting a growing influence of genetic factors on neurophysiological traits across the lifespan. Notably, this alignment is strongest in late adolescence, a critical period when genetic factors significantly shape brain individuality. Overall, our findings advance our understanding of the evolving biological foundations of inter-individual differences.
| Type: | Article |
|---|---|
| Title: | The lifespan evolution of individualized neurophysiological traits |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2025.116657 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2025.116657 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Published by Elsevier Inc. 1 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | CP: neuroscience, aging, brain fingerprint, genetics, inter-individual differences, magnetoencephalography, neural dynamics, neurodevelopment, neurophysiology, spectral power |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10219565 |
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