Yoo, Shin Hyuk;
Heo, Soon Chul;
Bae, Jun Sang;
Lee, Jun Hee;
Knowles, Jonathan C;
Kim, Hae-Won;
(2025)
Intranasal delivery systems for traumatic brain injury: Advancements and perspectives.
Journal of Tissue Engineering
, 16
pp. 1-29.
10.1177/20417314251372373.
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Abstract
Traumatic brain injury (TBI) is a major cause of mortality and morbidity, commonly leading to long-term impairments in cognition, sensorimotor function, and personality. While neuroprotective drugs have demonstrated some efficacy in vitro cultures and in vivo animal models, their clinical applications remain debated. Intranasal delivery to the brain parenchyma, bypassing the blood-brain barrier for more direct access to target sites, offers a favorable and safe approach. This review illuminates current advancements in intranasal delivery systems for TBI treatment. We begin with an overview of TBI and its current clinical treatment options. We then outline recent developments in intranasal delivery systems of molecules and cells, emphasizing their efficacy in animal models. Finally, we discuss future clinical perspectives on emerging trends, offering insights into leveraging intranasal delivery for effective TBI therapeutics.
| Type: | Article |
|---|---|
| Title: | Intranasal delivery systems for traumatic brain injury: Advancements and perspectives |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/20417314251372373 |
| Publisher version: | https://doi.org/10.1177/20417314251372373 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Traumatic brain injury, intranasal delivery, stem cells, nanoparticles, regeneration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214046 |
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