Devine, Kerri;
Villalobos, Elisa;
Kyle, Catriona J;
Andrew, Ruth;
Reynolds, Rebecca M;
Stimson, Roland H;
Nixon, Mark;
(2023)
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action.
Nature Reviews Endocrinology
, 19
(2)
pp. 112-124.
10.1038/s41574-022-00745-9.
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Abstract
Responses to hormones that act through nuclear receptors are controlled by modulating hormone concentrations not only in the circulation but also within target tissues. The role of enzymes that amplify or reduce local hormone concentrations is well established for glucocorticoid and other lipophilic hormones; moreover, transmembrane transporters have proven critical in determining tissue responses to thyroid hormones. However, there has been less consideration of the role of transmembrane transport for steroid hormones. ATP-binding cassette (ABC) proteins were first shown to influence the accumulation of glucocorticoids in cells almost three decades ago, but observations over the past 10 years suggest that differential transport propensities of both exogenous and endogenous glucocorticoids by ABCB1 and ABCC1 transporters provide a mechanism whereby different tissues are preferentially sensitive to different steroids. This Review summarizes this evidence and the new insights provided for the physiology and pharmacology of glucocorticoid action, including new approaches to glucocorticoid replacement.
| Type: | Article |
|---|---|
| Title: | The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41574-022-00745-9 |
| Publisher version: | https://doi.org/10.1038/s41574-022-00745-9 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 11-BETA-HYDROXYSTEROID DEHYDROGENASE, ADDISONS-DISEASE, BLOOD-BRAIN-BARRIER, DRUG TRANSPORTER, Endocrinology & Metabolism, Life Sciences & Biomedicine, MDR1A P-GLYCOPROTEIN, MULTIDRUG-RESISTANCE PROTEIN-1, PITUITARY-ADRENAL AXIS, PLASMA-CORTICOSTERONE, REPLACEMENT THERAPY, Science & Technology, TISSUE DISTRIBUTION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213194 |
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