Haarsma, Joost;
Kok, Peter;
(2025)
How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.
Current Topics in Behavioral Neurosciences
pp. 1-32.
10.1007/7854_2025_595.
(In press).
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Abstract
Perceptual disturbances occur across various sensory domains and contribute to significant suffering in numerous psychiatric and neurological conditions. Despite decades of research into the neural mechanisms underlying these distressing experiences, progress has been relatively limited. Here we explore the potential of layer-specific fMRI to enhance our understanding of these phenomena. We posit that perceptual disturbances can stem from alterations in the neural integration of internally generated signals-such as memory, imagination, prediction, and expectations-with sensory evidence being used to optimize inferences about the world. Emerging evidence suggests that these key computations are distributed across different cortical layers, highlighting the utility of layer-specific imaging in identifying the mechanisms driving such disruptions. We review recent findings that underscore the promise of layer-specific fMRI in elucidating these neural processes and discuss how pharmacological layer-specific fMRI could further advance this understanding. Finally, we address the current limitations of layer-specific fMRI and the progress made toward overcoming these challenges.
| Type: | Article |
|---|---|
| Title: | How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/7854_2025_595 |
| Publisher version: | https://doi.org/10.1007/7854_2025_595 |
| Language: | English |
| Additional information: | This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10212064 |
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