Bubna-Litic, M;
Mayor, R;
(2025)
Beyond mechanosensing: How cells sense and shape their physical environment during development.
Current Opinion in Cell Biology
, 94
, Article 102514. 10.1016/j.ceb.2025.102514.
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Abstract
The role of mechanics as a regulator of cell behaviour and embryo development has been widely recognised. However, much of the focus in mechanobiology during embryo development has been on how the mechanical properties of a cell affect its behaviour and fate determination. We discuss the role of mechanosignalling in development and propose that an equally important aspect of embryo mechanobiology is understanding how dynamic changes in tissue mechanics are regulated. Comparably to how chemical signals influence the fate of responding tissues during embryonic induction, we suggest that embryonic cell populations can alter the mechanical properties of adjacent tissues in a process we name ‘actuation’. Several examples of embryonic actuation and mechanical feedback are discussed.
| Type: | Article |
|---|---|
| Title: | Beyond mechanosensing: How cells sense and shape their physical environment during development |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceb.2025.102514 |
| Publisher version: | https://doi.org/10.1016/j.ceb.2025.102514 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Animals, Mechanotransduction, Cellular, Humans, Embryonic Development, Biomechanical Phenomena |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10209691 |
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