Marston, Louise;
Moncrieff, Joanna;
Priebe, Stefan;
Cro, Suzie;
Cornelius, Victoria R;
(2025)
Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand.
Journal of Clinical Epidemiology
, Article 111753. 10.1016/j.jclinepi.2025.111753.
(In press).
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Abstract
Objective: Many trials are affected by unforeseen events after recruitment has commenced. The aim of this study is to explore a hypothetical strategy for dealing with an intercurrent event that occurred during trial follow-up; COVID-19 restrictions.// Study Design and Setting: Secondary analysis of a randomised controlled trial in schizophrenia, comparing antipsychotic reduction versus maintenance medication on the Social Functioning Scale (SFS) score at 12 months’ follow-up. A hypothetical analysis strategy was used to estimate the treatment effect in a COVID-19 restriction-free world. Outcome data were set to missing and multiple imputation was used to replace values affected by COVID-19.// Results: The trial randomised 253 participants, 187 participants had an SFS score at 12 months, 75 of those were collected during COVID-19 restrictions. In the original complete case regression analysis, targeting a treatment policy estimand, the treatment effect was estimated to be 0.51 (95%CI -1.33, 2.35) points higher in the reduction group. After multiple imputation, targeting the hypothetical estimand, the mean SFS score was -3.01 (95%CI -7.22, 1.20) points lower in the reduction group, but varied with different assumptions about the timing of events and in sensitivity analyses to increase the size of difference between randomised groups.// Conclusion: We demonstrated how the intervention effect can change when estimating the intervention effect in a pandemic world (treatment policy estimand) versus a pandemic restriction-free world (hypothetical estimand) and that estimates are sensitive to imputation and input assumptions. Trialists should be aware of potential intercurrent events and plan the analysis to take them into account.
| Type: | Article |
|---|---|
| Title: | Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jclinepi.2025.111753 |
| Publisher version: | https://doi.org/10.1016/j.jclinepi.2025.111753 |
| Language: | English |
| Additional information: | © The Author(s), 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | COVID-19, estimands, missing data, multiple imputation, randomised controlled trial, social functioning |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10205884 |
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