Lee, Matthew T;
Martorana, Vincenzo;
Md, Rafizul I;
Sivera, Raphael;
Cook, Andrew C;
Menezes, Leon;
Burriesci, Gaetano;
... Bosi, Giorgia M; + view all
(2024)
On preserving anatomical detail in statistical shape analysis for clustering: focus on left atrial appendage morphology.
Frontiers in Network Physiology
, 4
, Article 1467180. 10.3389/fnetp.2024.1467180.
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Abstract
INTRODUCTION: Statistical shape analysis (SSA) with clustering is often used to objectively define and categorise anatomical shape variations. However, studies until now have often focused on simplified anatomical reconstructions, despite the complexity of studied anatomies. This work aims to provide insights on the anatomical detail preservation required for SSA of highly diverse and complex anatomies, with particular focus on the left atrial appendage (LAA). This anatomical region is clinically relevant as the location of almost all left atrial thrombi forming during atrial fibrillation (AF). Moreover, its highly patient-specific complex architecture makes its clinical classification especially subjective. METHODS: Preliminary LAA meshes were automatically detected after robust image selection and wider left atrial segmentation. Following registration, four additional LAA mesh datasets were created as reductions of the preliminary dataset, with surface reconstruction based on reduced sample point densities. Utilising SSA model parameters determined to optimally represent the preliminary dataset, SSA model performance for the four simplified datasets was calculated. A representative simplified dataset was selected, and clustering analysis and performance were evaluated (compared to clinical labels) between the original trabeculated LAA anatomy and the representative simplification. RESULTS: As expected, simplified anatomies have better SSA evaluation scores (compactness, specificity and generalisation), corresponding to simpler LAA shape representation. However, oversimplification of shapes may noticeably affect 3D model output due to differences in geometric correspondence. Furthermore, even minor simplification may affect LAA shape clustering, where the adjusted mutual information (AMI) score of the clustered trabeculated dataset was 0.67, in comparison to 0.12 for the simplified dataset. DISCUSSION: This study suggests that greater anatomical preservation for complex and diverse LAA morphologies, currently neglected, may be more useful for shape categorisation via clustering analyses.
| Type: | Article |
|---|---|
| Title: | On preserving anatomical detail in statistical shape analysis for clustering: focus on left atrial appendage morphology |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnetp.2024.1467180 |
| Publisher version: | https://doi.org/10.3389/fnetp.2024.1467180 |
| Language: | English |
| Additional information: | © 2024 Lee, Martorana, Md, Sivera, Cook, Menezes, Burriesci, Torii and Bosi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Statistical shape analysis, hierarchical clustering, left atrial appendage (LAA), atrial fibrillation, principal component analysis -PCA, clustering performance evaluation, segmentation (image processing) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10198375 |
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