Narasimhan, Sneha;
Holtzman, David M;
Apostolova, Liana G;
Cruchaga, Carlos;
Masters, Colin L;
Hardy, John;
Villemagne, Victor L;
... Hampel, Harald; + view all
(2024)
Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway.
Nature Neuroscience
, 27
(7)
pp. 1236-1252.
10.1038/s41593-024-01669-5.
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Abstract
Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) has remained the strongest single genome-wide associated risk variant in AD. Scientific advances in APOE biology, AD pathophysiology and ApoE-targeted therapies have brought APOE to the forefront of research, with potential translation into routine AD clinical care. This contemporary Review will merge APOE research with the emerging AD clinical care pathway and discuss APOE genetic risk as a conduit to genomic-based precision medicine in AD, including ApoE’s influence in the ATX(N) biomarker framework of AD. We summarize the evidence for APOE as an important modifier of AD clinical–biological trajectories. We then illustrate the utility of APOE testing and the future of ApoE-targeted therapies in the next-generation AD clinical–diagnostic pathway. With the emergence of new AD therapies, understanding how APOE modulates AD pathophysiology will become critical for personalized AD patient care.
| Type: | Article |
|---|---|
| Title: | Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41593-024-01669-5 |
| Publisher version: | http://dx.doi.org/10.1038/s41593-024-01669-5 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | A-BETA, APOE GENOTYPE, CEREBRAL AMYLOID ANGIOPATHY, E EPSILON-4, GENETIC RISK, Life Sciences & Biomedicine, MOUSE MODEL, Neurosciences, Neurosciences & Neurology, OLDER-ADULTS, ONSET, Science & Technology, SEX, TAU-MEDIATED NEURODEGENERATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10196930 |
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