Xin, Zhang; Ghoreishizadeh, Sara; (2024) Detecting Deterioration in Electrochemical Sensing Au Electrodes with Admittance Measurement. In: Proceedings of the 2024 BioSensors Conference (BioSensors). IEEE (Institute of Electrical and Electronics Engineers): Cambridge, UK. (In press).

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Abstract

This paper assesses the impact of deterioration induced by biofouling and halide-mediated passivation (HMP) on the electrochemical impedance and sensing performance of gold screen-printed electrodes (SPEs). Two sets of experiments were carried out in phosphate-buffered saline (PBS) solution which contains chloride ion (to cause HMP) and the same buffer solution enriched with mucin protein (to cause biofouling as well as HMP). The results confirm the existence and role of biofouling and HMP in degrading sensing performance. A decline of more than 50% in sensitivity was set as a threshold for sensor end of lifetime or failure. Concurrent electrochemical impedance spectroscopy labelled with sensor status (healthy, failed) was used to train a decision tree-based classification. A near 100% accuracy was achieved in predicting the sensor health state using only one feature: sensor admittance at a single frequency.

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