Bulik, Cynthia M;
Micali, Nadia;
Macdermod, Casey M;
Qi, Baiyu;
Munn-Chernoff, Melissa A;
Thornton, Laura M;
White, Jennifer;
... Crowley, James J; + view all
(2023)
ARFID Genes and Environment (ARFID-GEN): study protocol.
BMC Psychiatry
, 23
(1)
, Article 863. 10.1186/s12888-023-05266-x.
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Abstract
Background: The Avoidant Restrictive Food Intake Disorder – Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver “actionable” findings that can be transformed into clinically meaningful insights. Trial registration: ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.
| Type: | Article |
|---|---|
| Title: | ARFID Genes and Environment (ARFID-GEN): study protocol |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s12888-023-05266-x |
| Publisher version: | http://dx.doi.org/10.1186/s12888-023-05266-x |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Psychiatry, Avoidant restrictive food intake disorder, Picky eating, Selective eating, Eating disorders, Genome-wide association, Psychiatric genetics, Psychiatric genomics consortium, Social media, REVISED CHILD ANXIETY, COPY-NUMBER VARIATION, FOOD-INTAKE DISORDER, EATING-DISORDER, PSYCHOMETRIC PROPERTIES, DEPRESSION SCALE, PARENT VERSION, SHORT-FORM, QUESTIONNAIRE, VALIDATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10187857 |
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