Lim, Shu En;
Vicente-Munuera, Pablo;
Mao, Yanlan;
(2024)
Forced back into shape: Mechanics of epithelial wound repair.
Current Opinion in Cell Biology
, 87
, Article 102324. 10.1016/j.ceb.2024.102324.
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Abstract
Wound repair, the closing of a hole, is inherently a physical process that requires the change of shape of materials, in this case, cells and tissues. Not only is efficient and accurate wound repair critical for restoring barrier function and reducing infection, but it is also critical for restoring the complex three-dimensional architecture of an organ. This re-sculpting of tissues requires the complex coordination of cell behaviours in multiple dimensions, in space and time, to ensure that the repaired structure can continue functioning optimally. Recent evidence highlights the importance of cell and tissue mechanics in 2D and 3D to achieve such seamless wound repair.
| Type: | Article |
|---|---|
| Title: | Forced back into shape: Mechanics of epithelial wound repair |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceb.2024.102324 |
| Publisher version: | http://dx.doi.org/10.1016/j.ceb.2024.102324 |
| Language: | English |
| Additional information: | © 2024 The Authors. Published by Elsevier Ltd. under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Mechanics, Tissue repair, Wound healing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10186611 |
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