Pressler, Ronit;
Auvin, Stéphane;
(2013)
Comparison of brain maturation among species: an example in translational research suggesting the possible use of bumetanide in newborn.
Frontiers in Neurology
, 4
, Article 36. 10.3389/fneur.2013.00036.
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Abstract
The therapeutic need for neurological diseases requires the pursuit of research in this area by the development of new models of brain diseases as well as preclinical drug studies. Among them, the development of medicines for newborns has been identified as an urgent need for both preclinical and clinical research (Silverstein et al., 2008). This would lead to more translational studies on the developing brain. However, there are certain risks involved in this translation from animal models to humans such as the effect on brain maturation, safety, and co-morbidity. Interpretation of results of preclinical drug studies requires a knowledge of brain maturation among species in particular when the efficacy or the safety of a drug may be different. Moreover, the risk benefit ratio of a drug in development should also be considered in the interpretation of translational studies.
| Type: | Article |
|---|---|
| Title: | Comparison of brain maturation among species: an example in translational research suggesting the possible use of bumetanide in newborn |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fneur.2013.00036 |
| Publisher version: | https://doi.org/10.3389/fneur.2013.00036 |
| Language: | English |
| Additional information: | © 2013 Pressler and Auvin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10177151 |
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