González-García, Nadia;
Buimer, Elizabeth EL;
Moreno-López, Laura;
Sallie, Samantha N;
Váša, František;
Lim, Sol;
Romero-Garcia, Rafael;
... van Harmelen, Anne-Laura; + view all
(2023)
Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity.
Development and Psychopathology
pp. 1-11.
10.1017/s0954579423000901.
(In press).
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Abstract
Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14–24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning.
| Type: | Article |
|---|---|
| Title: | Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1017/s0954579423000901 |
| Publisher version: | https://doi.org/10.1017/S0954579423000901 |
| Language: | English |
| Additional information: | © The Author(s), 2023. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | resilience, childhood adversity, brain networks structural covariance, adolescence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10174407 |
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