Zhu, Wenhui;
Li, Weifen;
Jiang, Jian;
Wang, Dilong;
Mao, Xinliang;
Zhang, Jin;
Zhang, Xunzhi;
... Li, Ningning; + view all
(2023)
Chronic salmon calcitonin exerts an antidepressant effect via modulating the p38 MAPK signaling pathway.
Frontiers in Molecular Neuroscience
, 16
, Article 1071327. 10.3389/fnmol.2023.1071327.
Preview |
Text
fnmol-16-1071327.pdf - Published Version Download (3MB) | Preview |
Abstract
Depression is a common recurrent psychiatric disorder with a high lifetime prevalence and suicide rate. At present, although several traditional clinical drugs such as fluoxetine and ketamine, are widely used, medications with a high efficiency and reduced side effects are of urgent need. Our group has recently reported that a single administration of salmon calcitonin (sCT) could ameliorate a depressive-like phenotype via the amylin signaling pathway in a mouse model established by chronic restraint stress (CRS). However, the molecular mechanism underlying the antidepressant effect needs to be addressed. In this study, we investigated the antidepressant potential of sCT applied chronically and its underlying mechanism. In addition, using transcriptomics, we found the MAPK signaling pathway was upregulated in the hippocampus of CRS-treated mice. Further phosphorylation levels of ERK/p38/JNK kinases were also enhanced, and sCT treatment was able only to downregulate the phosphorylation level of p38/JNK, with phosphorylated ERK level unaffected. Finally, we found that the antidepressant effect of sCT was blocked by p38 agonists rather than JNK agonists. These results provide a mechanistic explanation of the antidepressant effect of sCT, suggesting its potential for treating the depressive disorder in the clinic.
| Type: | Article |
|---|---|
| Title: | Chronic salmon calcitonin exerts an antidepressant effect via modulating the p38 MAPK signaling pathway |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnmol.2023.1071327 |
| Publisher version: | https://doi.org/10.3389/fnmol.2023.1071327 |
| Language: | English |
| Additional information: | © 2023 Zhu, Li, Jiang, Wang, Mao, Zhang, Zhang, Chang, Yao, Yang, Da Costa, Zhang, Yu, Li, Li, Chi and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Chronic restraint stress, depression, hippocampus, p38/JNK signaling pathway, salmon calcitonin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10167419 |
Archive Staff Only
 |
View Item |
