Zhang, Ying;
Alshaikhi, Jailan;
Tan, Wenyong;
Royle, Gary J;
Bär, Esther;
(2022)
A probability model for anatomical robust optimisation in head and neck cancer proton therapy.
Physics in Medicine & Biology
10.1088/1361-6560/aca877.
(In press).
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Abstract
Objective: Develop an anatomical model based on the statistics of the population data and evaluate the model for anatomical robust optimisation in head and neck (H\&N) cancer proton therapy. Approach: Deformable Image Registration (DIR) was used to build the probability model (PM) that captured the major deformation from patient population data and quantified the probability of each deformation. A cohort of 20 nasopharynx patients was included in this retrospective study. Each patient had a planning CT and 6 weekly CTs during radiotherapy. We applied the model to 5 test patients. Each test patient used the remaining 19 training patients to build the PM and estimate the likelihood of a certain anatomical deformation to happen. For each test patient, a spot-scanning proton plan was created. The PM was evaluated using proton spot location deviation and dose distribution. Main results: Using the proton spot range, the PM can simulate small non-rigid variations in the first treatment week within 0.21 ±0.13 mm. For overall anatomical uncertainty prediction, the PM can reduce anatomical uncertainty from 4.47±1.23 mm (no model) to 1.49±1.08 mm at week 6. The 95% confidence interval (CI) of dose metric variations caused by actual anatomical deformations in the first week is -0.59 ± -0.31 % for low-risk CT D95, and 0.84±3.04 Gy for parotid Dmean. On the other hand, the 95% CI of dose metric variations simulated by the PM at the first week is -0.52 ± -0.34\% for low-risk CTV D95, and 0.58 ±2.22 Gy for parotid Dmean. Significance: The PM improves the estimation accuracy of anatomical uncertainty compared to the previous models and does not depend on the acquisition of the weekly CTs during the treatment. We provided a solution to quantify the probability of an anatomical deformation. The potential of the model for anatomical robust optimisation is discussed.
| Type: | Article |
|---|---|
| Title: | A probability model for anatomical robust optimisation in head and neck cancer proton therapy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1361-6560/aca877 |
| Language: | English |
| Additional information: | As the Version of Record of this article is going to be/has been published on a gold open access basis under a CC BY 3.0 licence, this Accepted Manuscript is available for reuse under a CC BY 3.0 licence immediately. Although reasonable endeavours have been taken to obtain all necessary permissions from third parties to include their copyrighted content within this article, their full citation and copyright line may not be present in this Accepted Manuscript version. Before using any content from this article, please refer to the Version of Record on IOPscience once published for full citation and copyright details, as permission may be required. All third party content is fully copyright protected, and is not published on a gold open access basis under a CC BY licence, unless that is specifically stated in the figure caption in the Version of Record. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10161699 |
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