UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Transmissible human proteopathies: an expanding field

Jaunmuktane, Z; Brandner, S; (2022) Transmissible human proteopathies: an expanding field. Diagnostic Histopathology , 28 (9) pp. 417-423. 10.1016/j.mpdhp.2022.07.002. Green open access

[thumbnail of Brandner_Transmissible human proteopathies. An expanding field_AAM.pdf]
Preview
Text
Brandner_Transmissible human proteopathies. An expanding field_AAM.pdf - Accepted Version

Download (919kB) | Preview

Abstract

Prions are considered the prototype of transmissible proteopathies, and this property has for many decades been considered unique. More recently the transmissibility of other misfolded proteins, notably Aβ, tau and synuclein, has been recognized. Initially, the transmission of these proteins was shown experimentally but the relevance for humans was debated. The co-transmission of Aβ with prions through medical procedures involving preparations derived from cadaveric human tissues, such as human growth hormone treatment, dura mater transplants or the use of neurosurgical instruments carrying traces of Aβ protein has fundamentally changed the opinion in the field. In this article, we will summarize the key features of the most common neurodegenerative diseases involving protein misfolding and their established or potential role in disease transmission.

Type: Article
Title: Transmissible human proteopathies: an expanding field
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mpdhp.2022.07.002
Publisher version: https://doi.org/10.1016/j.mpdhp.2022.07.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: α-synuclein, Alzheimer's disease, amyloid-β, CJD, Creutzfeldt-Jakob disease, neurodegeneration, neurodegenerative disease, Parkinson's disease, prion disease, prions, proteopathy, tau, tauopathy
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10157979
Downloads since deposit
12Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item