Klein, Brittany A;
Shazib, Muhammad Ali;
Villa, Alessandro;
de Abreu Alves, Fábio;
Vacharotayangul, Piamkamon;
Sonis, Stephen;
Fedele, Stefano;
(2022)
Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider.
Frontiers in Oral Health
, 3
, Article 968157. 10.3389/froh.2022.968157.
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Abstract
Immune checkpoint inhibitors (ICIs) are a revolutionary class of antineoplastic therapy that restore anti-tumor immunity. Consequences of this enhanced immune response include a multitude of immune related adverse events (irAEs) that can affect any body system, including the mouth. Orofacial irAEs reproduce features of numerous immune-mediated conditions, including oral lichen planus, mucous membrane pemphigoid, and Sjögren syndrome, among others. The aim of this review is to summarize known orofacial irAEs and to familiarize oral healthcare providers with how to identify and manage these toxicities as part of the care team for patients treated with ICIs.
| Type: | Article |
|---|---|
| Title: | Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/froh.2022.968157 |
| Publisher version: | https://doi.org/10.3389/froh.2022.968157 |
| Language: | English |
| Additional information: | © 2022 Klein, Shazib, Villa, de Abreu Alves, Vacharotayangul, Sonis, Fedele and Treister. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | cancer, immunotherapy, oral medicine, oral pathology, toxicity |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10156083 |
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