Barutta, Federica;
Bellini, Stefania;
Guarrera, Simonetta;
Matullo, Giuseppe;
Schalkwijk, Casper;
Stehouwer, Coen D;
Chaturvedi, Nish;
... Gruden, Gabriella; + view all
(2022)
Association of serum MicroRNA-145-5p levels with microvascular complications of type 1 Diabetes: The EURODIAB prospective complications study.
Diabetes Research and Clinical Practice
, 190
, Article 109987. 10.1016/j.diabres.2022.109987.
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Abstract
Aims: To investigate whether serum miR-145-5p levels were associated with micro-macrovascular chronic complications in patients with type 1 diabetes (DM1). Methods: A nested case-control study from the EURODIAB Prospective Complications Study was performed. Cases (n = 289) had one or more complications of diabetes, whereas controls (n = 153) did not have any complication. We measured miR-145-5p levels by qPCR and investigated the association with diabetes complications. Results: Mean miR-145-5p levels were significantly lower in cases with microangiopathy [2.12 (0.86–4.94)] compared to controls [3.15 (1.21–7.36), P < 0.05] even after adjustment for age, gender, and diabetes duration. In logistic regression analysis, miR-145-5p levels in the lowest tertile were associated with an over three-fold increased odds ratio (OR) of albuminuria [3.22 (1.17–8.81)], independently of both demographic and diabetes-related factors. In addition, mir145-5p levels in the lowest tertile were independently and inversely associated with arterial hypertension [1.96 (1.08–3.56)] and hypertension was the mediator of the relationship between miR-145-5p and albuminuria. Conclusions: In this large cohort of DM1 patients, we found an inverse association between miR-145-5p and albuminuria that was mediated by systemic hypertension.
| Type: | Article |
|---|---|
| Title: | Association of serum MicroRNA-145-5p levels with microvascular complications of type 1 Diabetes: The EURODIAB prospective complications study |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.diabres.2022.109987 |
| Publisher version: | https://doi.org/10.1016/j.diabres.2022.109987 |
| Language: | English |
| Additional information: | © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Type 1 diabetes, microRNAs, Diabetic complications, Cardiovascular diseases, Hypertension, Albuminuria, Diabetic nephropathy, Diabetic kidney disease, TGF-beta 1, SMOOTH-MUSCLE-CELLS, CARDIOVASCULAR-DISEASE, CIRCULATING MICRORNAS, EXPRESSION, RETINOPATHY, MECHANISMS, BIOMARKERS, TARGETS, MARKERS, MIRNAS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10153529 |
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