Poort, J;
Wilmes, KA;
Blot, A;
Chadwick, A;
Sahani, M;
Clopath, C;
Mrsic-Flogel, TD;
... Khan, AG; + view all
(2021)
Learning and attention increase visual response selectivity through distinct mechanisms.
Neuron
10.1016/j.neuron.2021.11.016.
(In press).
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Abstract
Selectivity of cortical neurons for sensory stimuli can increase across days as animals learn their behavioral relevance and across seconds when animals switch attention. While both phenomena occur in the same circuit, it is unknown whether they rely on similar mechanisms. We imaged primary visual cortex as mice learned a visual discrimination task and subsequently performed an attention switching task. Selectivity changes due to learning and attention were uncorrelated in individual neurons. Selectivity increases after learning mainly arose from selective suppression of responses to one of the stimuli but from selective enhancement and suppression during attention. Learning and attention differentially affected interactions between excitatory and PV, SOM, and VIP inhibitory cells. Circuit modeling revealed that cell class-specific top-down inputs best explained attentional modulation, while reorganization of local functional connectivity accounted for learning-related changes. Thus, distinct mechanisms underlie increased discriminability of relevant sensory stimuli across longer and shorter timescales.
| Type: | Article |
|---|---|
| Title: | Learning and attention increase visual response selectivity through distinct mechanisms |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2021.11.016 |
| Publisher version: | https://doi.org/10.1016/j.neuron.2021.11.016 |
| Language: | English |
| Additional information: | © 2021 The Authors. Published by Elsevier Inc. Available under the Creative Commons Attribution (CC BY 4.0) license |
| Keywords: | GABAergic interneurons, attention, learning, neural circuits, plasticity, visual cortex |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neurosci Unit UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10140772 |
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