Leung, AK-W;
Kondo, Y;
Krummel, DAP;
Li, J;
Price, SR;
van Roon, A-MM;
(2021)
Engineering Crystal Packing in RNA-Protein Complexes II: A Historical Perspective from the Structural Studies of the Spliceosome.
Crystals
, 11
(8)
, Article 948. 10.3390/cryst11080948.
Preview |
Text
crystals-11-00948-v2.pdf - Published Version Download (3MB) | Preview |
Abstract
Cryo-electron microscopy has greatly advanced our understanding of how the spliceosome cycles through different conformational states to conduct the chemical reactions that remove introns from pre-mRNA transcripts. The Cryo-EM structures were built upon decades of crystallographic studies of various spliceosomal RNA-protein complexes. In this review we give an overview of the crystal structures solved in the Nagai group, utilizing many of the strategies to design crystal packing as described in the accompanying paper.
| Type: | Article |
|---|---|
| Title: | Engineering Crystal Packing in RNA-Protein Complexes II: A Historical Perspective from the Structural Studies of the Spliceosome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/cryst11080948 |
| Publisher version: | https://doi.org/10.3390/cryst11080948 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| Keywords: | Crystallography, Materials Science, Multidisciplinary, Materials Science, crystallization, RNA-protein complexes, spliceosome, SNRNP CORE-DOMAIN, U1 SNRNP, KISSING COMPLEX, RESOLUTION, CRYSTALLIZATION, ASSOCIATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134224 |
Archive Staff Only
 |
View Item |
