McCutcheon, RA;
Brown, K;
Nour, MM;
Smith, SM;
Veronese, M;
Zelaya, F;
Osugo, M;
... Howes, OD; + view all
(2021)
Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness.
Science Advances
, 7
(24)
, Article eabg1512. 10.1126/sciadv.abg1512.
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Abstract
Dopamine signaling is constrained to discrete tracts yet has brain-wide effects on neural activity. The nature of this relationship between local dopamine signaling and brain-wide neuronal activity is not clearly defined and has relevance for neuropsychiatric illnesses where abnormalities of cortical activity and dopamine signaling coexist. Using simultaneous PET-MRI in healthy volunteers, we find strong evidence that patterns of striatal dopamine signaling and cortical blood flow (an index of local neural activity) contain shared information. This shared information links amphetamine-induced changes in gradients of striatal dopamine receptor availability to changes in brain-wide blood flow and is informed by spatial patterns of gene expression enriched for genes implicated in schizophrenia, bipolar disorder, and autism spectrum disorder. These results advance our knowledge of the relationship between cortical function and striatal dopamine, with relevance for understanding pathophysiology and treatment of diseases in which simultaneous aberrations of these systems exist.
| Type: | Article |
|---|---|
| Title: | Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/sciadv.abg1512 |
| Publisher version: | https://doi.org/10.1126/sciadv.abg1512 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, HUMAN CEREBRAL-CORTEX, PET, RELEASE, NEUROTRANSMISSION, SEGMENTATION, CONNECTIVITY, ACTIVATION, SYSTEM, MODEL, LEADS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10129732 |
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