Nigrovic, PA;
Colbert, RA;
Holers, VM;
Ozen, S;
Ruperto, N;
Thompson, SD;
Wedderburn, LR;
... Martini, A; + view all
(2021)
Biological classification of childhood arthritis: roadmap to a molecular nomenclature.
Nature Reviews Rheumatology
, 17
pp. 257-269.
10.1038/s41584-021-00590-6.
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Abstract
Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course. Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least one phenotype might be restricted to children. Nevertheless, paediatric and adult rheumatologists have historically addressed disease classification separately, yielding a juvenile idiopathic arthritis (JIA) nomenclature that exhibits no terminological overlap with adult-onset arthritis. Accumulating clinical, genetic and mechanistic data reveal the critical limitations of this strategy, necessitating a new approach to defining biological categories within JIA. In this Review, we provide an overview of the current evidence for biological subgroups of arthritis in children, delineate forms that seem contiguous with adult-onset arthritis, and consider integrative genetic and bioinformatic strategies to identify discrete entities within inflammatory arthritis across all ages.
| Type: | Article |
|---|---|
| Title: | Biological classification of childhood arthritis: roadmap to a molecular nomenclature |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41584-021-00590-6 |
| Publisher version: | https://doi.org/10.1038/s41584-021-00590-6 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Juvenile idiopathic arthritis, Molecular medicine, Paediatric research |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10126356 |
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