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Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement

Keck, T; (2020) Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement. Neuron , 108 (3) pp. 397-399. 10.1016/j.neuron.2020.10.018. Green open access

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Abstract

Cheadle et al. reveal that microglia expressing TWEAK facilitate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway during visual circuit development. This mechanism is experience-dependent and occurs through the local binding of TWEAK to postsynaptic Fn14.

Type: Article
Title: Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2020.10.018
Publisher version: https://doi.org/10.1016/j.neuron.2020.10.018
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10115015
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