Sommerlad, A;
Sabia, S;
Livingston, G;
Kivimäki, M;
Lewis, G;
Singh-Manoux, A;
(2020)
Leisure activity participation and risk of dementia: 18 year follow-up of the Whitehall II Study.
Neurology
10.1212/WNL.0000000000010966.
(In press).
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Abstract
Objective: To test the hypothesis that leisure activity participation is associated with lower dementia risk, we examined the association between participation in leisure activities and incident dementia in a large longitudinal study with average 18-year follow-up. / Methods: We used data from 8,280 participants of the Whitehall II prospective cohort study. A 13-item scale assessed leisure activity participation in 1997–99, 2002–04, and 2007–09 and incidence of dementia (n cases = 360, mean age at diagnosis 76.2 years, incidence rate = 2.4 per 1,000 person-years) was ascertained from 3 comprehensive national registers with follow-up until March 2017. Primary analyses were based on complete cases (n = 6,050, n cases = 247) and sensitivity analyses used multiple imputation for missing data. / Results: Participation in leisure activities at mean age 55.8 (1997–99 assessment), with 18.0-year follow-up, was not associated with dementia (hazard ratio [HR] 0.92, 95% CI 0.79–1.06) but those with higher participation at mean age 65.7 (2007–09 assessment) were less likely to develop dementia with 8.3-year follow-up (HR 0.82 [0.69–0.98]). No specific type of leisure activity was consistently associated with dementia risk. Decline in participation between 1997–99 and 2007–09 was associated with subsequent dementia risk. / Conclusion: Our findings suggest that participation in leisure activities declines in the preclinical phase of dementia; there was no robust evidence for a protective association between leisure activity participation and dementia. Future research should investigate the socio-behavioural, cognitive, and neurobiological drivers of decline in leisure activity participation to determine potential approaches to improving social participation of those developing dementia.
| Type: | Article |
|---|---|
| Title: | Leisure activity participation and risk of dementia: 18 year follow-up of the Whitehall II Study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1212/WNL.0000000000010966 |
| Publisher version: | https://doi.org/10.1212/WNL.0000000000010966 |
| Language: | English |
| Additional information: | Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10113482 |
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