Ryom, L;
Lundgren, JD;
Reiss, P;
Ross, M;
Kirk, O;
Fux, CA;
Morlat, P;
... D:A:D Study Group; + view all
(2021)
The impact of immunosuppression on chronic kidney disease in people living with HIV; the D:A:D study.
The Journal of Infectious Diseases
, 223
(4)
pp. 632-637.
10.1093/infdis/jiaa396.
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Abstract
BACKGROUND: Relations between different measures of HIV-related immunosuppression and chronic kidney disease (CKD) remain unknown. METHODS: Immunosuppression measures included baseline, current, time-lagged and nadir CD4, years and percentage of follow-up (%FU) with CD4<200, and CD4 recovery. CKD: confirmed estimated glomerular filtration rate <60mL/min/1.73m2. RESULTS: Of 33,791 persons 2,226 developed CKD. Univariably, all immunosuppression measures predicted CKD. Multivariably, the strongest predictor was %FU CD4<200 (0 vs. >25%, IRR 0.77 [0.68-0.88]) with highest effect in those at low D:A:D CKD risk (0.45 [0.24-0.80]) vs. 0.80 [0.70-0.93]). CONCLUSION: Longer immunosuppression duration most strongly predicts CKD and affects persons at low CKD risk more.
| Type: | Article |
|---|---|
| Title: | The impact of immunosuppression on chronic kidney disease in people living with HIV; the D:A:D study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/infdis/jiaa396 |
| Publisher version: | https://doi.org/10.1093/infdis/jiaa396 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CD4, CKD, HIV, Immunosuppression, chronic kidney disease, eGFR, renal |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10105250 |
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