Neidle, S;
(2017)
Quadruplex nucleic acids as targets for anticancer therapeutics.
Nature Reviews Chemistry
, 1
(5)
, Article 0041. 10.1038/s41570-017-0041.
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Abstract
Quadruplex nucleic acids — helical four-stranded structures known to form from guanine-rich nucleic acid sequences through Hoogsteen-type hydrogen bonding — were once just laboratory curiosities. However, they are now emerging from this rather obscure status to become important targets for small-molecule drugs, which can stabilize the quadruplex structures and thereby promote selective downregulation of gene expression and telomerase inhibition, and also activate DNA damage responses. Most of these quadruplex-binding small molecules can stabilize a range of cellular quadruplexes, as well as clusters of quadruplexes within a single gene or telomere, which could be an advantage. This widespread stabilization can generate a polygene response, and thus is able to simultaneously affect several key driver genes in human cancers, with potential therapeutic benefit.
| Type: | Article |
|---|---|
| Title: | Quadruplex nucleic acids as targets for anticancer therapeutics |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41570-017-0041 |
| Publisher version: | https://doi.org/10.1038/s41570-017-0041 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Drug discovery and development, Nucleic acids |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10096376 |
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