Quadruplex nucleic acids as targets for anticancer therapeutics

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Quadruplex nucleic acids as targets for anticancer therapeutics

Neidle, S; (2017) Quadruplex nucleic acids as targets for anticancer therapeutics. Nature Reviews Chemistry , 1 (5) , Article 0041. 10.1038/s41570-017-0041. Green open access

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Abstract

Quadruplex nucleic acids — helical four-stranded structures known to form from guanine-rich nucleic acid sequences through Hoogsteen-type hydrogen bonding — were once just laboratory curiosities. However, they are now emerging from this rather obscure status to become important targets for small-molecule drugs, which can stabilize the quadruplex structures and thereby promote selective downregulation of gene expression and telomerase inhibition, and also activate DNA damage responses. Most of these quadruplex-binding small molecules can stabilize a range of cellular quadruplexes, as well as clusters of quadruplexes within a single gene or telomere, which could be an advantage. This widespread stabilization can generate a polygene response, and thus is able to simultaneously affect several key driver genes in human cancers, with potential therapeutic benefit.

Type:	Article
Title:	Quadruplex nucleic acids as targets for anticancer therapeutics
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1038/s41570-017-0041
Publisher version:	https://doi.org/10.1038/s41570-017-0041
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords:	Drug discovery and development, Nucleic acids
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI:	https://discovery.ucl.ac.uk/id/eprint/10096376