Ravagli, Enrico;
Crescentini, Marco;
Rovatti, Paolo;
Severi, Stefano;
(2020)
Non-Invasive Estimation of Plasma Sodium Concentration During Hemodialysis via Capacitively-Coupled Electrical Impedance Spectroscopy.
IEEE Transactions on Instrumentation and Measurement
, 69
(4)
1673 -1681.
10.1109/tim.2019.2913612.
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Abstract
This paper presents a compact, low-cost, and noninvasive system for real-time estimation of plasma sodium concentration ([Na]Pl) during a hemodialysis (HD) session with state-of-the-art accuracy. It is based on electrical impedance spectroscopy (EIS) performed with a capacitively-coupled impedance sensing cell and a high-frequency measurement device, both custom-built. The EIS data are processed to infer the resistance of the liquid inside the cell, which is used together with an optical hemoglobin sensor to estimate the [Na]Pl. Validation of the EIS was performed by estimating the conductivity of bloodmimicking fluid (BMF). The complete method was validated using whole bovine blood, comparing the results to those obtained with standard instruments. The system was able to estimate the [Na]Pl with sufficient accuracy (RMS error of 3.0 mol/m3 with respect to reference data) to provide clinically useful information. The proof-of-concept hardware can be converted to a cheap and compact circuit board for integration into an HD machine.
| Type: | Article |
|---|---|
| Title: | Non-Invasive Estimation of Plasma Sodium Concentration During Hemodialysis via Capacitively-Coupled Electrical Impedance Spectroscopy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/tim.2019.2913612 |
| Publisher version: | https://doi.org/10.1109/tim.2019.2913612 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Biomedical Measurement, Blood, Hemodialysis, Impedance Spectroscopy, Instrumentation, Sodium |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10084365 |
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