Bainbridge, WA;
Berron, D;
Schütze, H;
Cardenas-Blanco, A;
Metzger, C;
Dobisch, L;
Bittner, D;
... Düzel, E; + view all
(2019)
Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment.
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
, 11
pp. 610-618.
10.1016/j.dadm.2019.07.005.
(In press).
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Abstract
Introduction: Impaired long-term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this impairment is item specific, limited to some memoranda, whereas some remain consistently memorable. Methods: We conducted item-based analyses of long-term visual recognition memory. Three hundred ninety-four participants (healthy controls, subjective cognitive decline [SCD], and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs. Results: We observed consistent memorability for images in healthy controls, SCD, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set. Discussion: Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.
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