Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode

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Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode

Zanelli, J; Mollon, J; Sandin, S; Morgan, C; Dazzan, P; Pilecka, I; Marques, T; ... Reichenberg, A; + view all (2019) Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode. American Journal of Psychiatry , 176 (10) pp. 811-819. 10.1176/appi.ajp.2019.18091088. Green open access

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Abstract

Objective: Schizophrenia is associated with a large cognitive impairment that is widely believed to remain stable after illness onset. Yet, even to date, 10-year prospective studies of cognitive functioning following the first episode with good methodology are rare. We examined whether schizophrenia patients experience cognitive decline following the first episode, whether this decline is generalized or confined to individual neuropsychological functions, and whether decline is specific to schizophrenia. Method: Participants were from a population-based, case-control study of patients with first-episode psychosis that were followed prospectively up to 10 years post first admission. A neuropsychological battery was administered at index presentation and at follow-up to patients with a diagnosis of schizophrenia (n=65), or other psychoses (n=41), as well as to healthy comparison subjects (n=103). Results: The schizophrenia group exhibited declines in IQ and in measures of verbal knowledge, and memory, but not processing speed or executive functions. Processing speed and executive function impairments were already present at the first episode and remained stable thereafter. Magnitude of declines ranged between 0.28 and 0.66 standard deviations. Decline in measures of memory was not specific to schizophrenia and was also apparent in the group of patients with other psychoses. Healthy individuals with low IQ, on the other hand, showed no evidence of decline, suggesting that a decline is specific to psychosis. Conclusions: Patients with schizophrenia and other psychoses experience cognitive decline after illness onset, but the magnitude of decline varies across cognitive functions. Distinct mechanisms consequent upon the illness and/or psychosocial factors may underlie impairments across different cognitive functions.

Type:	Article
Title:	Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1176/appi.ajp.2019.18091088
Publisher version:	https://doi.org/10.1176/appi.ajp.2019.18091088
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI:	https://discovery.ucl.ac.uk/id/eprint/10076981