George, J;
Giannoni, L;
Meng, LJ;
(2019)
Energy-modulated x-ray fluorescence and luminescence emissions from therapeutic nanoparticles.
Physics in Medicine and Biology
, 64
(3)
, Article 035020. 10.1088/1361-6560/aaeec3.
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Abstract
In this study, we have investigated the possibility of modulating x-ray fluorescence (XF) and x-ray luminescence (XL) emissions from therapeutic nanoparticles (NPs) by fine-tuning the energy of incident x-rays from benchtop x-ray sources. We have carried out detailed experimental studies to determine the strength of XF and XL emissions from Y2O3:Eu3+ and LaF3:Tb3+ NPs being irradiated with x-rays from benchtop x-ray sources operated with different tube-voltages and coupled to various filter configurations. These studies demonstrated that low-energy x-rays with average energy at around 10-15 keV are the most efficient to stimulate XL emission from the Y2O3:Eu3+ and LaF3:Tb3+ NPs. The efficiency falls quickly when x-ray energies go above or below the optimum energy range. As one would expect, x-rays with average energy just above the corresponding absorption edge of the target metal would be the most efficient in inducing XF emission. In this study, we have also demonstrated that one could fine-tune the incident x-ray energy to modulate the XL and XF emissions, such as (a) selectively inducing either XL or XF emission from the same type of NPs, (b) inducing preferential XL activation of Y2O3:Eu3+ over LaF3:Eu3+ or controlling the ratio of XL activation of these two types of NPs, and (c) introducing preferential XF emission from one type of NPs over the other. As a potential application, one could optimize the energy-characteristics of the incident x-rays to facilitate multiplexed combinatorial delivery of photodynamic therapy (X-PDT), where different agents could be administrated and then selectively activated in user-defined spatial and temporal patterns to fulfill combinatorial therapeutic effects. The understanding gained through this study could prove critical for enhancing the therapeutic delivery in X-PDT, and for attaining high-quality x-ray fluorescence computed tomography (XFCT) and x-ray luminescence computed tomography (XLCT) images while minimizing the x-ray dose to the sample.
| Type: | Article |
|---|---|
| Title: | Energy-modulated x-ray fluorescence and luminescence emissions from therapeutic nanoparticles |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1361-6560/aaeec3 |
| Publisher version: | https://doi.org/10.1088/1361-6560/aaeec3 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | XFCT, XLCT, X-PDT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10070046 |
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