Wu, J;
Sebastian, RT;
Chu, CJ;
McGregor, F;
Dick, AD;
Liu, L;
(2019)
Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography.
Current Eye Research
, 44
(5)
pp. 533-540.
10.1080/02713683.2018.1563195.
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Abstract
AIMS: To evaluate retinal vasculature changes in primary open angle glaucoma (POAG) and whether the functional visual loss correlates with parameters obtained using optical coherence tomography angiography (OCTA). MATERIALS AND METHODS: OCT and OCTA images were collected from 116 POAG eyes and 40 normal eyes in a prospective, cross-sectional observational study. Glaucomatous eyes were further divided into three groups according to a Glaucoma Staging System. Measurements of macular vessel density, ganglion cell complex (GCC), and disc retinal nerve fibre layer (RNFL) thickness were compared among groups. RESULTS: The macular vessel density, GCC, and RNFL are significantly reduced in POAG compared to normal eyes that also corresponds to the severity of glaucoma (Kruskal-Wallis test with Dunnett's correction; p < 0.0001). Visual field mean deviation correlates significantly with macular vessel density (p = 0.0028, r = 0.3), GCC (p < 0.0001, r = 0.6), and RNFL (p = 0.008, r = 0.36) in POAG. There are significant correlations between GCC and RNFL (p < 0.0001, r = 0.76) as well as macular vessel density (p < 0.0001, r = 0.48). Increased age also correlates with reduced macular vessel density in both normal (p = 0.0002, r = 0.49) and glaucomatous eyes (p < 0.0001, r = 0.48), but a greater proportionate reduction of vessel density is seen in glaucomatous eyes. CONCLUSION: Reduced macular vessel density occurs in POAG despite of age-related changes, which also correlates with reductions in RNFL and GCC measurements. OCTA can detect microstructural defects and offers potential to facilitate diagnosis of glaucoma.
| Type: | Article |
|---|---|
| Title: | Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/02713683.2018.1563195 |
| Publisher version: | https://doi.org/10.1080/02713683.2018.1563195 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Glaucoma, OCTA, field of vision, intraocular pressure, macula, optic nerve |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10065107 |
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