Orczyk, C;
Rosenkrantz, AB;
Mikheev, A;
Villers, A;
Bernaudin, M;
Taneja, SS;
Valable, S;
(2017)
3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy.
Academic Radiology
, 24
(12)
pp. 1544-1555.
10.1016/j.acra.2017.06.010.
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Abstract
RATIONAL AND OBJECTIVE: This study aimed to assess a novel method of three-dimensional (3D) co-registration of prostate magneticresonance imaging (MRI) examinations performed before and after prostate cancer focal therapy. MATERIAL AND METHODS: We developed a software platform for automatic 3D deformable co-registration of prostate MRI at different timepoints and applied this method to 10 patients who underwent focal ablative therapy . MRI examinations were performed preoperatively, aswell as 1 week and 6 months post treatment. Rigid registration served as reference for assessing co-registration accuracy and precision. RESULTS: Segmentation of preoperative and postoperative prostate revealed a significant postoperative volume decrease of the glandthat averaged 6.49 cc (P = .017). Applying deformable transformation based on mutual information from 120 pairs of MRI slices, werefined by 2.9 mm (max. 6.25 mm) the alignment of the ablation zone, segmented from contrast-enhanced images on the 1-week post-operative examination, to the 6-month postoperative T2-weighted images. This represented a 500% improvement over the rigid approach(P = .001), corrected by volume. The dissimilarity by Dice index of the mapped ablation zone using deformable transformation vs rigidcontrol was significantly (P = .04) higher at the ablation site than in the whole gland. CONCLUSION: Our findings illustrate our method’s ability to correct for deformation at the ablation site. The preliminary analysis sug-gests that deformable transformation computed from mutual information of preoperative and follow-up MRI is accurate in co-registration of MRI examinations performed before and after focal therapy. The ability to localize the previously ablated tissue in 3Dspace may improve targeting for image-guided follow-up biopsy within focal therapy protocols.
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