Nikolić, MZ;
Rawlins, EL;
(2017)
Lung Organoids and Their Use To Study Cell-Cell Interaction.
Current Pathobiology Reports
, 5
(2)
pp. 223-231.
10.1007/s40139-017-0137-7.
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Abstract
The use of co-culture organoid systems has facilitated the in vitro cultivation of previously inaccessible stem cell populations, providing a novel method for dissecting the molecular requirements of these cell-cell interactions. Future technology development will allow the growth of epithelial-only organoids in more defined media and also the introduction of specific non-epithelial cells for the study of cell interactions. These developments will require an improved understanding of the epithelial and non-epithelial cell types present in the lung and their lineage relationships.
| Type: | Article |
|---|---|
| Title: | Lung Organoids and Their Use To Study Cell-Cell Interaction |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s40139-017-0137-7 |
| Publisher version: | http://doi.org/10.1007/s40139-017-0137-7 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Organoids, Lung progenitors, Mouse lung, Human lung, iPSCs |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051183 |
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