Villanueva, M;
Garcia, B;
Valle, J;
Rapun, B;
Ruiz de los Mozos, I;
Solano, C;
Marti, M;
... Lasa, I; + view all
(2018)
Sensory deprivation in Staphylococcus aureus.
Nature Communications
, 9
, Article 523. 10.1038/s41467-018-02949-y.
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Abstract
Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions. Characterization of S. aureus derivatives containing individual TCSs reveals that each TCS appears to be autonomous and self-sufficient to sense and respond to specific environmental cues, although some level of cross-regulation between non-cognate sensor-response regulator pairs occurs in vivo. This organization, if confirmed in other bacterial species, may provide a general evolutionarily mechanism for flexible bacterial adaptation to life in new niches.
| Type: | Article |
|---|---|
| Title: | Sensory deprivation in Staphylococcus aureus |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-018-02949-y |
| Publisher version: | https://doi.org/10.1038/s41467-018-02949-y |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, 2-COMPONENT SIGNAL-TRANSDUCTION, GRAM-POSITIVE BACTERIA, ESCHERICHIA-COLI, BIOFILM FORMATION, CROSS-TALK, IN-VITRO, PHOSPHATASE-ACTIVITY, CELL-CYCLE, SYSTEM, VIRULENCE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10048734 |
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