Skillbäck, T;
Lautner, R;
Mattsson, N;
Schott, JM;
Nägga, K;
Kilander, L;
Wimo, A;
... Zetterberg, H; + view all
(2018)
Apolipoprotein E genotypes and longevity across dementia disorders.
Alzheimer's & Dementia
, 14
(7)
pp. 895-901.
10.1016/j.jalz.2018.02.003.
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Abstract
INTRODUCTION: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. METHODS: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. RESULTS: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. DISCUSSION: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.
| Type: | Article |
|---|---|
| Title: | Apolipoprotein E genotypes and longevity across dementia disorders |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jalz.2018.02.003 |
| Publisher version: | https://doi.org/10.1016/j.jalz.2018.02.003 |
| Language: | English |
| Additional information: | © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer's disease, Apolipoprotein E, Creutzfeldt-Jakob disease, Dementia with Lewy bodies, Frontotemporal dementia, Parkinson's disease dementia, Vascular dementia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047022 |
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