Pineda, M;
Eftimie, R;
(2017)
Modelling the collective response of heterogeneous cell populations to stationary gradients and chemical signal relay.
Physical Biology
, 14
(6)
, Article 066003. 10.1088/1478-3975/aa89b4.
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Abstract
The directed motion of cell aggregates toward a chemical source occurs in many relevant biological processes. Understanding the mechanisms that control this complex behavior is of great relevance for our understanding of developmental biological processes and many diseases. In this paper, we consider a self-propelled particle model for the movement of heterogeneous subpopulations of chemically interacting cells towards an imposed stable chemical gradient. Our simulations show explicitly how self-organisation of cell populations (which could lead to engulfment or complete cell segregation) can arise from the heterogeneity of chemotactic responses alone. This new result complements current theoretical and experimental studies that emphasise the role of differential cell–cell adhesion on self-organisation and spatial structure of cellular aggregates. We also investigate how the speed of individual cell aggregations increases with the chemotactic sensitivity of the cells, and decreases with the number of cells inside the aggregates.
| Type: | Article |
|---|---|
| Title: | Modelling the collective response of heterogeneous cell populations to stationary gradients and chemical signal relay |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1478-3975/aa89b4 |
| Publisher version: | http://doi.org/10.1088/1478-3975/aa89b4 |
| Language: | English |
| Additional information: | © 2017 IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10045840 |
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